Publication

Primary Sjögren’s Syndrome: towards a new era in diagnosis, treatment and e-patient education

Delli, K., 2017, [Groningen]: University of Groningen. 255 p.

Research output: ThesisThesis fully internal (DIV)Academic

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  • Title and contents

    Final publisher's version, 82 KB, PDF document

  • Chapter 1

    Final publisher's version, 66 KB, PDF document

  • Chapter 2

    Final publisher's version, 384 KB, PDF document

  • Chapter 3A

    Final publisher's version, 362 KB, PDF document

  • Chapter 3B

    Final publisher's version, 34 KB, PDF document

  • Chapter 3C

    Final publisher's version, 227 KB, PDF document

  • Chapter 3D

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  • Chapter 3E

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  • Chapter 3F

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  • Chapter 4A

    Final publisher's version, 224 KB, PDF document

  • Chapter 4B

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  • Chapter 4C

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  • Chapter 5A

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  • Chapter 5B

    Final publisher's version, 155 KB, PDF document

  • Chapter 6

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  • Chapter 7

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  • Chapter 8

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  • Complete thesis

    Final publisher's version, 2 MB, PDF document

  • Propositions

    Final publisher's version, 184 KB, PDF document

Sjögren’s syndrome (SS) is an autoimmune disease that typically affects the salivary and tear glands, causing dry mouth and dry eyes. SS patients also commonly feel tired and physically exhausted.
In order to diagnose SS several diagnostic tests are commonly performed. Recently, salivary gland ultrasonography has drawn a lot of attention as a new diagnostic tool in SS because it is a fast, painless, non-invasive and non-irradiating method. As far as treatment is concerned, rituximab, which targets B-cells, has been shown to reduce symptoms in patients. It is not known, however, which patient will benefit from this treatment. Finally, nowadays it is very likely that patients as well as their care givers may search the Internet for information on the progression of the disease, its complaints and treatment possibilities, but the quality of this information has not been evaluated.
The studies described in this thesis have revealed that salivary gland ultrasonography is an accurate technique to diagnose SS and should get a place in the diagnostic work-up. Additionally, we showed that treatment with rituximab decreased the inflammation in salivary glands, as well as that patients with SS who have a high number of B-cells in the salivary glands best responded to this treatment. Thus, treatment of SS patients can probably be personalized. Finally, Web sites and YouTube videos dealing with SS had a highly variable quality. Only news agencies and university channels provided reliable information for SS. Thus, generally, there is a risk that patients with SS might be misinformed.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
Award date31-May-2017
Place of Publication[Groningen]
Publisher
Print ISBNs978-90-367-9789-4
Electronic ISBNs978-90-367-9788-7
Publication statusPublished - 2017

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