Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studiesHewitt, N. J., Lechon, M. J. G., Houston, J. B., Hallifax, D., Brown, H. S., Maurel, P., Kenna, J. G., Gustavsson, L., Lohmann, C., Skonberg, C., Guillouzo, A., Tuschl, G., Li, A. P., LeCluyse, E., Groothuis, G. M. M. & Hengstler, J. G., 2007, In : Drug metabolism reviews. 39, 1, p. 159-234 76 p.
Research output: Contribution to journal › Article › Academic › peer-review
This review brings you up-to-date with the hepatocyte research on: 1) in vitro-in vivo correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and crosstalk using human hepatocytes and hepatocyte-like cell lines; 3) the function and regulation of hepatic transporters and models used to elucidate their role in drug clearance; 4) mechanisms and examples of idiosyncratic and intrinsic hepatotoxicity; and 5) alternative cell systems to primary human hepatocytes. We also report pharmaceutical perspectives of these topics and compare methods and interpretations for the drug development process.
|Number of pages||76|
|Journal||Drug metabolism reviews|
|Publication status||Published - 2007|
|Event||1st Medicon Valley Hepatocyte User Form Symposium - , Denmark|
Duration: 26-Jan-2006 → 27-Jan-2006
1st Medicon Valley Hepatocyte User Form Symposium
26/01/2006 → 27/01/2006Denmark
- PREGNANE-X-RECEPTOR, CRYOPRESERVED HUMAN HEPATOCYTES, PRIMARY RAT HEPATOCYTES, HUMAN LIVER-MICROSOMES, IN-VITRO SYSTEMS, NONSTEROIDAL ANTIINFLAMMATORY DRUG, CONSTITUTIVE ANDROSTANE RECEPTOR, COLLAGEN-SANDWICH CONFIGURATION, HUMAN CYTOCHROME P4502B6, ADULT HUMAN HEPATOCYTES