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PREVENTION-ACHD: PRospEctiVE study on implaNTable cardioverter-defibrillator therapy and suddeN cardiac death in Adults with Congenital Heart Disease; Rationale and Design

Vehmeijer, J. T., Koyak, Z., Zwinderman, A. H., Harris, L., Peinado, R., Oechslin, E. N., Silversides, C. K., Bouma, B. J., Budts, W., van Gelder, I. C., Oliver, J. M., Mulder, B. J. M. & de Groot, J. R., Oct-2019, In : Netherlands Heart Hournal. 27, 10, p. 474-479 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • J. T. Vehmeijer
  • Z. Koyak
  • A. H. Zwinderman
  • L. Harris
  • R. Peinado
  • E. N. Oechslin
  • C. K. Silversides
  • B. J. Bouma
  • W. Budts
  • I. C. van Gelder
  • J. M. Oliver
  • B. J. M. Mulder
  • J. R. de Groot

Background Many adult congenital heart disease (ACHD) patients are at risk of sudden cardiac death (SCD). An implantable cardioverter-defibrillator (ICD) may prevent SCD, but the evidence for primary prevention indications is still unsatisfactory. Study Design PREVENTION-ACHD is a prospective study with which we aim to prospectively validate a new risk score model for primary prevention of SCD in ACHD patients, as well as the currently existing guideline recommendations. Patients are screened using a novel risk score to predict SCD as well as current ICD indications according to an international Consensus Statement. Patients are followed up for two years. The primary endpoint is the occurrence of SCD and sustained ventricular arrhythmias. The Study was registered at ClinicalTrials.gov (NCT03957824). Conclusion PREVENTION-ACHD is the first prospective study on SCD in ACHD patients. In the light of a growing and aging population of patients with more severe congenital heart defects, more robust clinical evidence on primary prevention of SCD is urgently needed.

Original languageEnglish
Pages (from-to)474-479
Number of pages6
JournalNetherlands Heart Hournal
Volume27
Issue number10
Publication statusPublished - Oct-2019

    Keywords

  • Risk score, Risk stratification, Ventricular tachycardia, Ventricular fibrillation, Primary prevention, POPULATION, PREVALENCE

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