Publication

Prevention and treatment of radiotherapy-induced side effects

Barazzuol, L., Coppes, R. P. & van Luijk, P., 24-Jun-2020, In : Molecular oncology. 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Barazzuol, L., Coppes, R. P., & van Luijk, P. (2020). Prevention and treatment of radiotherapy-induced side effects. Molecular oncology. https://doi.org/10.1002/1878-0261.12750

Author

Barazzuol, Lara ; Coppes, Rob P ; van Luijk, Peter. / Prevention and treatment of radiotherapy-induced side effects. In: Molecular oncology. 2020.

Harvard

Barazzuol, L, Coppes, RP & van Luijk, P 2020, 'Prevention and treatment of radiotherapy-induced side effects', Molecular oncology. https://doi.org/10.1002/1878-0261.12750

Standard

Prevention and treatment of radiotherapy-induced side effects. / Barazzuol, Lara; Coppes, Rob P; van Luijk, Peter.

In: Molecular oncology, 24.06.2020.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Barazzuol L, Coppes RP, van Luijk P. Prevention and treatment of radiotherapy-induced side effects. Molecular oncology. 2020 Jun 24. https://doi.org/10.1002/1878-0261.12750


BibTeX

@article{635309a125504687b27ef70945fe5b4c,
title = "Prevention and treatment of radiotherapy-induced side effects",
abstract = "Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50{\%} of patients. The precision with which the radiation dose can be delivered is rapidly improving. This precision allows the more accurate targeting of radiation dose to the tumor and reduces the amount of surrounding normal tissue exposed. Although this often reduces the unwanted side effects of radiotherapy, we still need to further improve patients' quality of life and to escalate radiation doses to tumors when necessary. High-precision radiotherapy forces one to choose which organ or functional organ substructures should be spared. To be able to make such choices, we urgently need to better understand the molecular and physiological mechanisms of normal tissue responses to radiotherapy. Currently, oversimplified approaches using constraints on mean doses, and irradiated volumes of normal tissues are used to plan treatments with minimized risk of radiation side effects. In this review, we discuss the responses of three different normal tissues to radiotherapy: the salivary glands, cardiopulmonary system, and brain. We show that although they may share very similar local cellular processes, they respond very differently through organ-specific, nonlocal mechanisms. We also discuss how a better knowledge of these mechanisms can be used to treat or to prevent the effects of radiotherapy on normal tissue and to optimize radiotherapy delivery.",
keywords = "brain, cardiopulmonary system, dose distribution, normal tissue effects, salivary gland, CENTRAL-NERVOUS-SYSTEM, RADIATION-INDUCED APOPTOSIS, SALIVARY-GLAND FUNCTION, STEM-CELLS, PAROTID-GLAND, GROWTH-FACTOR, NORMAL TISSUE, CELLULAR SENESCENCE, POTENTIAL ROLE, INDUCED DAMAGE",
author = "Lara Barazzuol and Coppes, {Rob P} and {van Luijk}, Peter",
note = "This article is protected by copyright. All rights reserved.",
year = "2020",
month = "6",
day = "24",
doi = "10.1002/1878-0261.12750",
language = "English",
journal = "Molecular oncology",
issn = "1574-7891",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Prevention and treatment of radiotherapy-induced side effects

AU - Barazzuol, Lara

AU - Coppes, Rob P

AU - van Luijk, Peter

N1 - This article is protected by copyright. All rights reserved.

PY - 2020/6/24

Y1 - 2020/6/24

N2 - Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of patients. The precision with which the radiation dose can be delivered is rapidly improving. This precision allows the more accurate targeting of radiation dose to the tumor and reduces the amount of surrounding normal tissue exposed. Although this often reduces the unwanted side effects of radiotherapy, we still need to further improve patients' quality of life and to escalate radiation doses to tumors when necessary. High-precision radiotherapy forces one to choose which organ or functional organ substructures should be spared. To be able to make such choices, we urgently need to better understand the molecular and physiological mechanisms of normal tissue responses to radiotherapy. Currently, oversimplified approaches using constraints on mean doses, and irradiated volumes of normal tissues are used to plan treatments with minimized risk of radiation side effects. In this review, we discuss the responses of three different normal tissues to radiotherapy: the salivary glands, cardiopulmonary system, and brain. We show that although they may share very similar local cellular processes, they respond very differently through organ-specific, nonlocal mechanisms. We also discuss how a better knowledge of these mechanisms can be used to treat or to prevent the effects of radiotherapy on normal tissue and to optimize radiotherapy delivery.

AB - Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of patients. The precision with which the radiation dose can be delivered is rapidly improving. This precision allows the more accurate targeting of radiation dose to the tumor and reduces the amount of surrounding normal tissue exposed. Although this often reduces the unwanted side effects of radiotherapy, we still need to further improve patients' quality of life and to escalate radiation doses to tumors when necessary. High-precision radiotherapy forces one to choose which organ or functional organ substructures should be spared. To be able to make such choices, we urgently need to better understand the molecular and physiological mechanisms of normal tissue responses to radiotherapy. Currently, oversimplified approaches using constraints on mean doses, and irradiated volumes of normal tissues are used to plan treatments with minimized risk of radiation side effects. In this review, we discuss the responses of three different normal tissues to radiotherapy: the salivary glands, cardiopulmonary system, and brain. We show that although they may share very similar local cellular processes, they respond very differently through organ-specific, nonlocal mechanisms. We also discuss how a better knowledge of these mechanisms can be used to treat or to prevent the effects of radiotherapy on normal tissue and to optimize radiotherapy delivery.

KW - brain

KW - cardiopulmonary system

KW - dose distribution

KW - normal tissue effects

KW - salivary gland

KW - CENTRAL-NERVOUS-SYSTEM

KW - RADIATION-INDUCED APOPTOSIS

KW - SALIVARY-GLAND FUNCTION

KW - STEM-CELLS

KW - PAROTID-GLAND

KW - GROWTH-FACTOR

KW - NORMAL TISSUE

KW - CELLULAR SENESCENCE

KW - POTENTIAL ROLE

KW - INDUCED DAMAGE

U2 - 10.1002/1878-0261.12750

DO - 10.1002/1878-0261.12750

M3 - Review article

C2 - 32521079

JO - Molecular oncology

JF - Molecular oncology

SN - 1574-7891

ER -

ID: 127406226