Publication

Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands

Wildenbeest, J. G., van der Schee, M. P., Hashimoto, S., Benschop, K. S. M., Minnaar, R. P., Sprikkelman, A. B., Haarman, E. G., van Aalderen, W. M. C., Sterk, P. J., Pajkrt, D. & Wolthers, K. C., Aug-2016, In : Clinical Microbiology and Infection. 22, 8, 7 p., ARTN 736.e9.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Wildenbeest, J. G., van der Schee, M. P., Hashimoto, S., Benschop, K. S. M., Minnaar, R. P., Sprikkelman, A. B., Haarman, E. G., van Aalderen, W. M. C., Sterk, P. J., Pajkrt, D., & Wolthers, K. C. (2016). Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands. Clinical Microbiology and Infection, 22(8), [ARTN 736.e9]. https://doi.org/10.1016/j.cmi.2016.05.022

Author

Wildenbeest, J. G. ; van der Schee, M. P. ; Hashimoto, S. ; Benschop, K. S. M. ; Minnaar, R. P. ; Sprikkelman, A. B. ; Haarman, E. G. ; van Aalderen, W. M. C. ; Sterk, P. J. ; Pajkrt, D. ; Wolthers, K. C. / Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands. In: Clinical Microbiology and Infection. 2016 ; Vol. 22, No. 8.

Harvard

Wildenbeest, JG, van der Schee, MP, Hashimoto, S, Benschop, KSM, Minnaar, RP, Sprikkelman, AB, Haarman, EG, van Aalderen, WMC, Sterk, PJ, Pajkrt, D & Wolthers, KC 2016, 'Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands', Clinical Microbiology and Infection, vol. 22, no. 8, ARTN 736.e9. https://doi.org/10.1016/j.cmi.2016.05.022

Standard

Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands. / Wildenbeest, J. G.; van der Schee, M. P.; Hashimoto, S.; Benschop, K. S. M.; Minnaar, R. P.; Sprikkelman, A. B.; Haarman, E. G.; van Aalderen, W. M. C.; Sterk, P. J.; Pajkrt, D.; Wolthers, K. C.

In: Clinical Microbiology and Infection, Vol. 22, No. 8, ARTN 736.e9, 08.2016.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Wildenbeest JG, van der Schee MP, Hashimoto S, Benschop KSM, Minnaar RP, Sprikkelman AB et al. Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands. Clinical Microbiology and Infection. 2016 Aug;22(8). ARTN 736.e9. https://doi.org/10.1016/j.cmi.2016.05.022


BibTeX

@article{e672597c8d4a4eecac99fe016e92d898,
title = "Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands",
abstract = "Rhinovirus (RV) is a frequent pathogen in young children, eliciting symptoms ranging from common colds to wheezing illnesses and lower respiratory tract infections. The recently identified RV-C seems to be associated with asthma exacerbations and more severe disease, but results vary. We studied the prevalence and severity of infection with RV in an unselected birth cohort. Children with respiratory symptoms entered the symptomatic arm of the cohort and were compared with asymptomatic children. Severity of wheezing and other respiratory symptoms was registered. Respiratory viruses were evaluated using throat and nasopharyngeal swabs on first presentation and after recovery (wheezing children). RV genotyping was performed on RV-PCR positive samples. RV was the most prevalent respiratory virus and was found in 58/140 symptomatic children (41%), 24/96 (25%) control children and 19/74 (26%) wheezing symptomatic children after recovery (p <0.05) and did not differ between wheezing and non-wheezing symptomatic children-respectively, 42% (38/90) and 40% (20/50). RV-A was the most commonly detected species (40/68, 59%), followed by RV-C (22/68, 32%) and RV-B (6/68, 9%). RV-B was more frequently detected in asymptomatic children (5/6, p <0.05). There was no significant difference in the frequency of RV species between wheezing and non-wheezing symptomatic children. Children with RV mono-infection had more severe symptoms, but no association between RV species and severity of disease was seen. In an unselected birth cohort from the Netherlands with mild respiratory disease RV was the most prevalent respiratory virus. RV(-C) infection was not associated with more severe disease or wheezing. J. G. Wildenbeest, (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.",
keywords = "Children, Rhinovirus, RV type C, Unselected birth cohort, Wheezing, RESPIRATORY-TRACT INFECTIONS, HOSPITALIZED CHILDREN, MOLECULAR EPIDEMIOLOGY, GENETIC DIVERSITY, ASTHMA, SEVERITY, ILLNESS, BRONCHIOLITIS, ASSOCIATION, CHILDHOOD",
author = "Wildenbeest, {J. G.} and {van der Schee}, {M. P.} and S. Hashimoto and Benschop, {K. S. M.} and Minnaar, {R. P.} and Sprikkelman, {A. B.} and Haarman, {E. G.} and {van Aalderen}, {W. M. C.} and Sterk, {P. J.} and D. Pajkrt and Wolthers, {K. C.}",
year = "2016",
month = aug,
doi = "10.1016/j.cmi.2016.05.022",
language = "English",
volume = "22",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "ELSEVIER SCI LTD",
number = "8",

}

RIS

TY - JOUR

T1 - Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands

AU - Wildenbeest, J. G.

AU - van der Schee, M. P.

AU - Hashimoto, S.

AU - Benschop, K. S. M.

AU - Minnaar, R. P.

AU - Sprikkelman, A. B.

AU - Haarman, E. G.

AU - van Aalderen, W. M. C.

AU - Sterk, P. J.

AU - Pajkrt, D.

AU - Wolthers, K. C.

PY - 2016/8

Y1 - 2016/8

N2 - Rhinovirus (RV) is a frequent pathogen in young children, eliciting symptoms ranging from common colds to wheezing illnesses and lower respiratory tract infections. The recently identified RV-C seems to be associated with asthma exacerbations and more severe disease, but results vary. We studied the prevalence and severity of infection with RV in an unselected birth cohort. Children with respiratory symptoms entered the symptomatic arm of the cohort and were compared with asymptomatic children. Severity of wheezing and other respiratory symptoms was registered. Respiratory viruses were evaluated using throat and nasopharyngeal swabs on first presentation and after recovery (wheezing children). RV genotyping was performed on RV-PCR positive samples. RV was the most prevalent respiratory virus and was found in 58/140 symptomatic children (41%), 24/96 (25%) control children and 19/74 (26%) wheezing symptomatic children after recovery (p <0.05) and did not differ between wheezing and non-wheezing symptomatic children-respectively, 42% (38/90) and 40% (20/50). RV-A was the most commonly detected species (40/68, 59%), followed by RV-C (22/68, 32%) and RV-B (6/68, 9%). RV-B was more frequently detected in asymptomatic children (5/6, p <0.05). There was no significant difference in the frequency of RV species between wheezing and non-wheezing symptomatic children. Children with RV mono-infection had more severe symptoms, but no association between RV species and severity of disease was seen. In an unselected birth cohort from the Netherlands with mild respiratory disease RV was the most prevalent respiratory virus. RV(-C) infection was not associated with more severe disease or wheezing. J. G. Wildenbeest, (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

AB - Rhinovirus (RV) is a frequent pathogen in young children, eliciting symptoms ranging from common colds to wheezing illnesses and lower respiratory tract infections. The recently identified RV-C seems to be associated with asthma exacerbations and more severe disease, but results vary. We studied the prevalence and severity of infection with RV in an unselected birth cohort. Children with respiratory symptoms entered the symptomatic arm of the cohort and were compared with asymptomatic children. Severity of wheezing and other respiratory symptoms was registered. Respiratory viruses were evaluated using throat and nasopharyngeal swabs on first presentation and after recovery (wheezing children). RV genotyping was performed on RV-PCR positive samples. RV was the most prevalent respiratory virus and was found in 58/140 symptomatic children (41%), 24/96 (25%) control children and 19/74 (26%) wheezing symptomatic children after recovery (p <0.05) and did not differ between wheezing and non-wheezing symptomatic children-respectively, 42% (38/90) and 40% (20/50). RV-A was the most commonly detected species (40/68, 59%), followed by RV-C (22/68, 32%) and RV-B (6/68, 9%). RV-B was more frequently detected in asymptomatic children (5/6, p <0.05). There was no significant difference in the frequency of RV species between wheezing and non-wheezing symptomatic children. Children with RV mono-infection had more severe symptoms, but no association between RV species and severity of disease was seen. In an unselected birth cohort from the Netherlands with mild respiratory disease RV was the most prevalent respiratory virus. RV(-C) infection was not associated with more severe disease or wheezing. J. G. Wildenbeest, (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

KW - Children

KW - Rhinovirus

KW - RV type C

KW - Unselected birth cohort

KW - Wheezing

KW - RESPIRATORY-TRACT INFECTIONS

KW - HOSPITALIZED CHILDREN

KW - MOLECULAR EPIDEMIOLOGY

KW - GENETIC DIVERSITY

KW - ASTHMA

KW - SEVERITY

KW - ILLNESS

KW - BRONCHIOLITIS

KW - ASSOCIATION

KW - CHILDHOOD

U2 - 10.1016/j.cmi.2016.05.022

DO - 10.1016/j.cmi.2016.05.022

M3 - Article

VL - 22

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 8

M1 - ARTN 736.e9

ER -

ID: 54030539