Publication

Prevalence of asymptomatic carotid artery stenosis in the general population: an individual participant data meta-analysis

de Weerd, M., Greving, J. P., Hedblad, B., Lorenz, M. W., Mathiesen, E. B., O'Leary, D. H., Rosvall, M., Sitzer, M., Buskens, E. & Bots, M. L., Jun-2010, In : Stroke. 41, 6, p. 1294-1297 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • de_Weerd_2010_Stroke

    Final publisher's version, 256 KB, PDF document

  • Download the document

    Final publisher's version, 199 KB, PDF document

DOI

  • Marjolein de Weerd
  • Jacoba P. Greving
  • Bo Hedblad
  • Matthias W. Lorenz
  • Ellisiv B. Mathiesen
  • Daniel H. O'Leary
  • Maria Rosvall
  • Matthias Sitzer
  • Erik Buskens
  • Michiel L. Bots

Background and Purpose-In the discussion on the cost-effectiveness of screening, precise estimates of severe asymptomatic carotid stenosis are vital. Accordingly, we assessed the prevalence of moderate and severe asymptomatic carotid stenosis by age and sex using pooled cohort data.

Methods-We performed an individual participant data meta-analysis (23 706 participants) of 4 population-based studies (Malmo Diet and Cancer Study, Tromso, Carotid Atherosclerosis Progression Study, and Cardiovascular Health Study). Outcomes of interest were asymptomatic moderate (>= 50%) and severe carotid stenosis (>= 70%).

Results-Prevalence of moderate asymptomatic carotid stenosis ranged from 0.2% (95% CI, 0.0% to 0.4%) in men aged = 80 years. For women, this prevalence increased from 0% (0% to 0.2%) to 5.0% (3.1% to 7.5%). Prevalence of severe asymptomatic carotid stenosis ranged from 0.1% (0.0% to 0.3%) in men aged = 80. For women, this prevalence increased from 0% (0.0% to 0.2%) to 0.9% (0.3% to 2.4%).

Conclusions-The prevalence of severe asymptomatic carotid stenosis in the general population ranges from 0% to 3.1%, which is useful information in the discussion on the cost-effectiveness of screening. (Stroke. 2010; 41: 1294-1297.)

Original languageEnglish
Pages (from-to)1294-1297
Number of pages4
JournalStroke
Volume41
Issue number6
Publication statusPublished - Jun-2010

    Keywords

  • carotid stenosis, epidemiology, stroke, RISK-FACTORS, ENDARTERECTOMY, PREVENTION, DISEASE, ATHEROSCLEROSIS, STROKE, MALMO, AGE

View graph of relations

ID: 5091926