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Prevalence and Etiology of Community-acquired Pneumonia in Immunocompromised Patients

GLIMP Investigators, Di Pasquale, M. F., Sotgiu, G., Gramegna, A., Radovanovic, D., Terraneo, S., Reyes, L. F., Rupp, J., del Castillo, J. G., Blasi, F., Aliberti, S. & Restrepo, M. I., 1-May-2019, In : Clinical Infectious Diseases. 68, 9, p. 1482-1493 12 p.

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  • Prevalence and Etiology of Community-acquired Pneumonia in Immunocompromised Patients

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DOI

  • GLIMP Investigators
  • Marta Francesca Di Pasquale
  • Giovanni Sotgiu
  • Andrea Gramegna
  • Dejan Radovanovic
  • Silvia Terraneo
  • Luis F. Reyes
  • Jan Rupp
  • Juan Gonzalez del Castillo
  • Francesco Blasi
  • Stefano Aliberti
  • Marcos I. Restrepo

Background. The correct management of immunocompromised patients with pneumonia is debated. We evaluated the prevalence, risk factors, and characteristics of immunocompromised patients coming from the community with pneumonia.

Methods. We conducted a secondary analysis of an international, multicenter study enrolling adult patients coming from the community with pneumonia and hospitalized in 222 hospitals in 54 countries worldwide. Risk factors for immunocompromise included AIDS, aplastic anemia, asplenia, hematological cancer, chemotherapy, neutropenia, biological drug use, lung transplantation, chronic steroid use, and solid tumor.

Results. At least 1 risk factor for immunocompromise was recorded in 18% of the 3702 patients enrolled. The prevalences of risk factors significantly differed across continents and countries, with chronic steroid use (45%), hematological cancer (25%), and chemotherapy (22%) the most common. Among immunocompromised patients, community-acquired pneumonia (CAP) pathogens were the most frequently identified, and prevalences did not differ from those in immunocompetent patients. Risk factors for immunocompromise were independently associated with neither Pseudomonas aeruginosa nor non-community-acquired bacteria. Specific risk factors were independently associated with fungal infections (odds ratio for AIDS and hematological cancer, 15.10 and 4.65, respectively; both P = .001), mycobacterial infections (AIDS; P = .006), and viral infections other than influenza (hematological cancer, 5.49; P <.001).

Conclusions. Our findings could be considered by clinicians in prescribing empiric antibiotic therapy for CAP in immunocompromised patients. Patients with AIDS and hematological cancer admitted with CAP may have higher prevalences of fungi, mycobacteria, and noninfluenza viruses.

Original languageEnglish
Pages (from-to)1482-1493
Number of pages12
JournalClinical Infectious Diseases
Volume68
Issue number9
Publication statusPublished - 1-May-2019

    Keywords

  • pneumonia, multidrug-resistant pathogens, microbiology, MRSA, immunocompromise, BLOOD-STREAM INFECTIONS, MULTIDRUG-RESISTANT PATHOGENS, RESPIRATORY-TRACT INFECTIONS, RISK-FACTORS, PNEUMOCYSTIS PNEUMONIA, TRANSPLANT RECIPIENTS, HOSPITALIZED-PATIENTS, BACTERIAL PNEUMONIA, DISEASES-SOCIETY, MANAGEMENT

ID: 96791038