Publication

Pre-stroke use of statins on stroke outcome: a meta-analysis of observational studies

Cordenier, A., De Smedt, A., Brouns, R., Uyttenboogaart, M., De Raedt, S., Luijckx, G-J. & De Keyser, J., Dec-2011, In : Acta neurologica belgica. 111, 4, p. 261-267 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Background: Animal pre-clinical studies suggest that statins may have neuroprotective effects in acute ischaemic stroke. Statins might also increase the risk of developing haemorrhagic transformation after thrombolytic treatment.

Methods: We performed a systematic review and included studies that compared good functional outcome, defined as a modified Rankin Scale (mRS) score

Results: Eleven studies met our predefined inclusion criteria. Statin therapy before stroke-onset was associated with a lower risk of in-hospital mortality (OR 0.56; 95% CI: 0.40 to 0.78, P <0.0006). There was no difference between the two groups for good functional outcome at 3 months (OR 1.01; 95% CI: 0.64 to 1.61, P = 0.96). Statin use was associated with an increased risk of developing symptomatic haemorrhagic transformation after thrombolytic therapy (OR 2.34; 95% CI 1.31 to 4.17, P = 0.004).

Conclusions: Our meta-analysis suggests that pretreatment with statins does not improve 3 months functional outcome, defined as independence on mRS, but decreases in-hospital mortality and increases the risk of developing a symptomatic haemorrhagic transformation in patients treated with thrombolysis.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalActa neurologica belgica
Volume111
Issue number4
Publication statusPublished - Dec-2011

    Keywords

  • Ischaemic stroke, statins, outcome, neuro-protection, thrombolysis, ICH, meta-analysis, ACUTE ISCHEMIC-STROKE, TISSUE-PLASMINOGEN ACTIVATOR, HEMORRHAGIC STROKE, NEUROPROTECTIVE PROPERTIES, MYOCARDIAL-INFARCTION, CHOLESTEROL LEVELS, PRETREATMENT, THROMBOLYSIS, PREVENTION, EVENTS

ID: 5495078