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Preparation of a Designed Poly(trimethylene carbonate) Microvascular Network by Stereolithography

Schuller-Ravoo, S., Zant, E., Feijen, J. & Grijpma, D. W., Dec-2014, In : Advanced healthcare materials. 3, 12, p. 2004-2011 8 p.

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  • Preparation of a Designed Poly(trimethylene carbonate) Microvascular Network by Stereolithography

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DOI

  • Sigrid Schuller-Ravoo
  • Erwin Zant
  • Jan Feijen
  • Dirk W. Grijpma

Designed flexible and elastic network structures are prepared by stereolithography using a photo-crosslinkable resin based on a poly(trimethylene carbonate) (PTMC) macromer with a molecular weight of 3150 g/mol. Physical properties and the compatibility with human umbilical vein endothelial cells (HUVECs) are evaluated. The hydrophobic networks are found to be flexible and elastic, with an E modulus of 7.9 +/- 0.1 MPa, a tensile strength of 3.5 +/- 0.1 MPa and an elongation at break of 76.7 +/- 0.7%. HUVECs attach and proliferate well on the surfaces of the built structures. A three-dimensional microvascular network is designed to serve as a perfusable scaffold for tissue engineering. In the design, 5 generations of open channels each branch into 4 smaller channels yielding a microvascular region with a high density of capillaries. The overall cross-sectional area through which medium or blood can be perfused remains constant. These structures would ensure efficient nourishment of cells in a large volume of tissue. Built by stereolithography using the PTMC resin, the smallest channels of these structures have square cross-sectional areas, with inner widths of approximately 224 mu m and wall thicknesses of approximately 152 mu m. The channels are open, allowing water to perfuse the scaffold at 0.279 +/- 0.006 mL/s at 80 mmHg and 0.335 +/- 0.009 mL/s at 120 mmHg.

Original languageEnglish
Pages (from-to)2004-2011
Number of pages8
JournalAdvanced healthcare materials
Volume3
Issue number12
Publication statusPublished - Dec-2014

    Keywords

  • IN-VIVO BEHAVIOR, EPSILON-CAPROLACTONE, TISSUE-RESPONSE, VASCULARIZATION, SCAFFOLDS, DEGRADATION, MICROFABRICATION, ANGIOGENESIS

ID: 15802504