Publication

Preparation of 3-alkyl-oxindoles by copper(II)-mediated C-H, Ar-H coupling followed by decarboxyalkylation

Pugh, D. S., Klein, J. E. M. N., Perry, A. & Taylor, R. J. K., 30-Mar-2010, In : Synlett. 6, p. 934-938 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

A novel route for the conversion of anilides into 3-alkyl-oxindoles is described in which a copper(II)-mediated cyclization process is followed by an acid-mediated decarboxyalkylation. Scope and limitation studies are reported together with a telescoped variant which incorporates in situ N-deprotection.

Original languageEnglish
Pages (from-to)934-938
Number of pages5
JournalSynlett
Issue number6
Publication statusPublished - 30-Mar-2010
Externally publishedYes

    Keywords

  • 3-alkyl-oxindoles, Anilides, C-H activation, Copper(II) catalysis, Cyclisation, Decarboxyalkylation, Oxindoles

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