Preparation of 3-alkyl-oxindoles by copper(II)-mediated C-H, Ar-H coupling followed by decarboxyalkylationPugh, D. S., Klein, J. E. M. N., Perry, A. & Taylor, R. J. K., 30-Mar-2010, In : Synlett. 6, p. 934-938 5 p.
Research output: Contribution to journal › Article › Academic › peer-review
A novel route for the conversion of anilides into 3-alkyl-oxindoles is described in which a copper(II)-mediated cyclization process is followed by an acid-mediated decarboxyalkylation. Scope and limitation studies are reported together with a telescoped variant which incorporates in situ N-deprotection.
|Number of pages||5|
|Publication status||Published - 30-Mar-2010|
- 3-alkyl-oxindoles, Anilides, C-H activation, Copper(II) catalysis, Cyclisation, Decarboxyalkylation, Oxindoles