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Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis

Biobank-based Integrative Omics, May-2019, In : Environmental Health Perspectives. 127, 5, 12 p., 057012.

Research output: Contribution to journalArticleAcademicpeer-review

  • Biobank-based Integrative Omics

Background: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes.

Objectives: We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameter

Methods: We meta-analyzed associations between exposure to PM10 (n=1,949) and PM2.5 (n=1,551) at maternal home addresses during pregnancy and newborn DNA methylation assessed by Illumina Infinium HumanMethylation450K BeadChip in nine European and American studies, with replication in 688 independent newborns and look-up analyses in 2,118 older children. We used two approaches, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs). We also related PM exposures to blood mRNA expression.

Results: Six CpGs were significantly associated [false discovery rate (FDR)

Conclusions: Several differentially methylated CpGs and DMRs associated with prenatal PM exposure were identified in newborns, with annotation to genes previously implicated in lung-related outcomes.

Original languageEnglish
Article number057012
Number of pages12
JournalEnvironmental Health Perspectives
Volume127
Issue number5
Publication statusPublished - May-2019

    Keywords

  • CHILDHOOD ASTHMA, LUNG DEVELOPMENT, GENE-EXPRESSION, CORD BLOOD, R-PACKAGE, ASSOCIATION, PREGNANCY, EXPOSURE, SUSCEPTIBILITY, MATTER

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