Publication

Prenatal and pubertal testosterone affect brain lateralization

Beking, T., Geuze, R. H., van Faassen, M., Kema, I. P., Kreukels, B. P. C. & Groothuis, T. G. G., Feb-2018, In : Psychoneuroendocrinology. 88, p. 78-91 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Beking, T., Geuze, R. H., van Faassen, M., Kema, I. P., Kreukels, B. P. C., & Groothuis, T. G. G. (2018). Prenatal and pubertal testosterone affect brain lateralization. Psychoneuroendocrinology, 88, 78-91. https://doi.org/10.1016/j.psyneuen.2017.10.027

Author

Beking, T ; Geuze, R H ; van Faassen, M ; Kema, I P ; Kreukels, B P C ; Groothuis, T G G. / Prenatal and pubertal testosterone affect brain lateralization. In: Psychoneuroendocrinology. 2018 ; Vol. 88. pp. 78-91.

Harvard

Beking, T, Geuze, RH, van Faassen, M, Kema, IP, Kreukels, BPC & Groothuis, TGG 2018, 'Prenatal and pubertal testosterone affect brain lateralization', Psychoneuroendocrinology, vol. 88, pp. 78-91. https://doi.org/10.1016/j.psyneuen.2017.10.027

Standard

Prenatal and pubertal testosterone affect brain lateralization. / Beking, T; Geuze, R H; van Faassen, M; Kema, I P; Kreukels, B P C; Groothuis, T G G.

In: Psychoneuroendocrinology, Vol. 88, 02.2018, p. 78-91.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Beking T, Geuze RH, van Faassen M, Kema IP, Kreukels BPC, Groothuis TGG. Prenatal and pubertal testosterone affect brain lateralization. Psychoneuroendocrinology. 2018 Feb;88:78-91. https://doi.org/10.1016/j.psyneuen.2017.10.027


BibTeX

@article{a865d1193dd84b14a5568d0a77be3f46,
title = "Prenatal and pubertal testosterone affect brain lateralization",
abstract = "After decades of research, the influence of prenatal testosterone on brain lateralization is still elusive, whereas the influence of pubertal testosterone on functional brain lateralization has not been investigated, although there is increasing evidence that testosterone affects the brain in puberty. We performed a longitudinal study, investigating the relationship between prenatal testosterone concentrations in amniotic fluid, pubertal testosterone concentrations in saliva, and brain lateralization (measured with functional Transcranial Doppler ultrasonography (fTCD)) of the Mental Rotation, Chimeric Faces and Word Generation tasks. Thirty boys and 30 girls participated in this study at the age of 15 years. For boys, we found a significant interaction effect between prenatal and pubertal testosterone on lateralization of Mental Rotation and Chimeric Faces. In the boys with low prenatal testosterone levels, pubertal testosterone was positively related to the strength of lateralization in the right hemisphere, while in the boys with high prenatal testosterone levels, pubertal testosterone was negatively related to the strength of lateralization. For Word Generation, pubertal testosterone was negatively related to the strength of lateralization in the left hemisphere in boys. For girls, we did not find any significant effects, possibly because their pubertal testosterone levels were in many cases below quantification limit. To conclude, prenatal and pubertal testosterone affect lateralization in a task-specific way. Our findings cannot be explained by simple models of prenatal testosterone affecting brain lateralization in a similar way for all tasks. We discuss alternative models involving age dependent effects of testosterone, with a role for androgen receptor distribution and efficiency.",
keywords = "Journal Article, ANDROGEN RECEPTOR GENE, CEREBRAL LATERALIZATION, SALIVARY TESTOSTERONE, LANGUAGE LATERALIZATION, FETAL TESTOSTERONE, SEXUAL-DIFFERENTIATION, HEMISPHERIC DOMINANCE, COGNITIVE CONTROL, ADOLESCENT BRAIN, DIGIT RATIO",
author = "T Beking and Geuze, {R H} and {van Faassen}, M and Kema, {I P} and Kreukels, {B P C} and Groothuis, {T G G}",
note = "Copyright {\circledC} 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2018",
month = "2",
doi = "10.1016/j.psyneuen.2017.10.027",
language = "English",
volume = "88",
pages = "78--91",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Prenatal and pubertal testosterone affect brain lateralization

AU - Beking, T

AU - Geuze, R H

AU - van Faassen, M

AU - Kema, I P

AU - Kreukels, B P C

AU - Groothuis, T G G

N1 - Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2018/2

Y1 - 2018/2

N2 - After decades of research, the influence of prenatal testosterone on brain lateralization is still elusive, whereas the influence of pubertal testosterone on functional brain lateralization has not been investigated, although there is increasing evidence that testosterone affects the brain in puberty. We performed a longitudinal study, investigating the relationship between prenatal testosterone concentrations in amniotic fluid, pubertal testosterone concentrations in saliva, and brain lateralization (measured with functional Transcranial Doppler ultrasonography (fTCD)) of the Mental Rotation, Chimeric Faces and Word Generation tasks. Thirty boys and 30 girls participated in this study at the age of 15 years. For boys, we found a significant interaction effect between prenatal and pubertal testosterone on lateralization of Mental Rotation and Chimeric Faces. In the boys with low prenatal testosterone levels, pubertal testosterone was positively related to the strength of lateralization in the right hemisphere, while in the boys with high prenatal testosterone levels, pubertal testosterone was negatively related to the strength of lateralization. For Word Generation, pubertal testosterone was negatively related to the strength of lateralization in the left hemisphere in boys. For girls, we did not find any significant effects, possibly because their pubertal testosterone levels were in many cases below quantification limit. To conclude, prenatal and pubertal testosterone affect lateralization in a task-specific way. Our findings cannot be explained by simple models of prenatal testosterone affecting brain lateralization in a similar way for all tasks. We discuss alternative models involving age dependent effects of testosterone, with a role for androgen receptor distribution and efficiency.

AB - After decades of research, the influence of prenatal testosterone on brain lateralization is still elusive, whereas the influence of pubertal testosterone on functional brain lateralization has not been investigated, although there is increasing evidence that testosterone affects the brain in puberty. We performed a longitudinal study, investigating the relationship between prenatal testosterone concentrations in amniotic fluid, pubertal testosterone concentrations in saliva, and brain lateralization (measured with functional Transcranial Doppler ultrasonography (fTCD)) of the Mental Rotation, Chimeric Faces and Word Generation tasks. Thirty boys and 30 girls participated in this study at the age of 15 years. For boys, we found a significant interaction effect between prenatal and pubertal testosterone on lateralization of Mental Rotation and Chimeric Faces. In the boys with low prenatal testosterone levels, pubertal testosterone was positively related to the strength of lateralization in the right hemisphere, while in the boys with high prenatal testosterone levels, pubertal testosterone was negatively related to the strength of lateralization. For Word Generation, pubertal testosterone was negatively related to the strength of lateralization in the left hemisphere in boys. For girls, we did not find any significant effects, possibly because their pubertal testosterone levels were in many cases below quantification limit. To conclude, prenatal and pubertal testosterone affect lateralization in a task-specific way. Our findings cannot be explained by simple models of prenatal testosterone affecting brain lateralization in a similar way for all tasks. We discuss alternative models involving age dependent effects of testosterone, with a role for androgen receptor distribution and efficiency.

KW - Journal Article

KW - ANDROGEN RECEPTOR GENE

KW - CEREBRAL LATERALIZATION

KW - SALIVARY TESTOSTERONE

KW - LANGUAGE LATERALIZATION

KW - FETAL TESTOSTERONE

KW - SEXUAL-DIFFERENTIATION

KW - HEMISPHERIC DOMINANCE

KW - COGNITIVE CONTROL

KW - ADOLESCENT BRAIN

KW - DIGIT RATIO

U2 - 10.1016/j.psyneuen.2017.10.027

DO - 10.1016/j.psyneuen.2017.10.027

M3 - Article

VL - 88

SP - 78

EP - 91

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -

ID: 54562187