Predictors of lifestyle intervention outcome and dropout: The SLIM study

Roumen, C., Feskens, E. J. M., Corpeleijn, E., Mensink, M., Saris, W. H. M. & Blaak, E. E., 2011, In : European Journal of Clinical Nutrition. 65, p. 1141-1147 7 p.

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  • Predictors of lifestyle intervention outcome and dropout:

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  • C Roumen
  • E J M Feskens
  • E Corpeleijn
  • M Mensink
  • W H M Saris
  • E E Blaak

BACKGROUND/OBJECTIVES: To evaluate the effect of a 4.1-year (range 3-6 years) lifestyle intervention according to general public health recommendations on glucose tolerance and dropout in a Dutch population with impaired glucose tolerance (IGT).

SUBJECTS/METHODS: In the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht, 147 Caucasian IGT subjects were randomized to an intervention group (INT: n=74; 38 male, 36 female) and control group (CON: n=73; 37 male, 36 female). Annually, subjects underwent measurements of body weight, anthropometry, glucose tolerance (oral glucose tolerance test), insulin resistance (homeostasis model assessment-insulin resistance), maximal aerobic capacity (VO(2) max), blood lipids and blood pressure. INT received individual advice regarding a healthy diet and physical activity.

RESULTS: INT decreased their saturated fat intake, increased their carbohydrate intake (P<0.05) and VO(2) max (P=0.04) compared with CON. Body weight did not change significantly (P=0.20) between the groups. After an initial decrease, 2-h glucose levels overall increased in INT (+0.11 mmol/l), but significantly less than CON (+1.18 mmol/l; P=0.04). Diabetes incidence was lower in INT versus CON (30 versus 56%, P=0.04). Change in body weight was associated with change in 2-h glucose levels (β=0.399 mmol/l per kg, P=0.02). Dropouts had a lower aerobic fitness and socioeconomic status, and a higher body mass index (BMI) and 2-h glucose compared with non-dropouts.

CONCLUSIONS: Prolonged feasible changes in diet and physical activity prevent deterioration of glucose tolerance and reduce diabetes risk. Low socioeconomic status, low aerobic fitness and high BMI and 2-h glucose are indicative of dropout to the program.

Original languageEnglish
Pages (from-to)1141-1147
Number of pages7
JournalEuropean Journal of Clinical Nutrition
Publication statusPublished - 2011
Externally publishedYes


  • Aged, Blood Glucose, Blood Pressure, Body Composition, Body Mass Index, Body Weight, Diabetes Mellitus, Type 2, Diet, Dietary Carbohydrates, Energy Intake, Female, Food, Organic, Glucose Intolerance, Glucose Tolerance Test, Humans, Life Style, Lipids, Male, Middle Aged, Motor Activity, Netherlands, Patient Dropouts, Risk Factors, Socioeconomic Factors, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

ID: 48411615