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Predicting the neurobehavioral side effects of dexamethasone in pediatric acute lymphoblastic leukemia

Warris, L. T., van den Akker, E. L. T., Aarsen, F. K., Bierings, M. B., van den Bos, C., Tissing, W. J. E., Sassen, S. D. T., Veening, M. A., Zwaan, C. M., Pieters, R. & van den Heuvel-Eibrink, M. M., Oct-2016, In : Psychoneuroendocrinology. 72, p. 190-195 6 p.

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  • Predicting the neurobehavioral side effects of dexamethasone in pediatric acute

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DOI

  • Lidewij T. Warris
  • Erica L. T. van den Akker
  • Femke K. Aarsen
  • Marc B. Bierings
  • Cor van den Bos
  • Wim J. E. Tissing
  • Sebastiaan D. T. Sassen
  • Margreet A. Veening
  • Christian M. Zwaan
  • Rob Pieters
  • Marry M. van den Heuvel-Eibrink

Although dexamethasone is an effective treatment for acute lymphoblastic leukemia (ALL), it can induce a variety of serious neurobehavioral side effects. We hypothesized that these side effects are influenced by glucocorticoid sensitivity at the tissue level. We therefore prospectively studied whether we could predict the occurrence of these side effects using the very low-dose dexamethasone suppression test (DST) or by measuring trough levels of dexamethasone. Fifty pediatric patients (3-16 years of age) with acute lymphoblastic leukemia (ALL) were initially included during the maintenance phase (with dexamethasone) of the Dutch ALL treatment protocol. As a marker of glucocorticoid sensitivity, the salivary very low-dose DST was used. A post-dexamethasone cortisol level

Original languageEnglish
Pages (from-to)190-195
Number of pages6
JournalPsychoneuroendocrinology
Volume72
Publication statusPublished - Oct-2016

    Keywords

  • Acute lymphoblastic leukemia, Pediatrics, Dexamethasone, Dexamethasone suppression test, Neurobehavioral problems, Predictors, GLUCOCORTICOID-RECEPTOR POLYMORPHISMS, ADRENAL INSUFFICIENCY, SALIVARY CORTISOL, CHILDREN, CHILDHOOD, THERAPY, CORTICOSTEROIDS, MOOD, VARIABILITY, SENSITIVITY

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