Predicting intestinal recovery after necrotizing enterocolitis in preterm infantsKuik, S. J., Kalteren, W. S., Mebius, M. J., Bos, A. F., Hulscher, J. B. F. & Kooi, E. M. W., Apr-2020, In : Pediatric Research. 87, 5, p. 903-909 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
BACKGROUND: Intestinal recovery after NEC is difficult to predict in individuals. We evaluated whether several biomarkers predict intestinal recovery after NEC in preterm infants.
METHODS: We measured intestinal tissue oxygen saturation (rintSO2) and collected urinary intestinal-fatty binding protein (I-FABPu) levels 0-24 h and 24-48 h after NEC onset, and before and after the first re-feed. We assessed intestinal recovery in two ways: time to full enteral feeding (FEFt; below or equal/above group's median) and development of post-NEC complications (recurrent NEC/post-NEC stricture). We determined whether the rintSO2, its range, and I-FABPu differed between groups.
RESULTS: We included 27 preterm infants who survived NEC (Bell's stage ≥ 2). Median FEFt was 14 [IQR: 12-23] days. Biomarkers only predicted intestinal recovery after the first re-feed. Mean rintSO2 ≥ 53% combined with mean rintSO2range ≥ 50% predicted FEFt < 14 days with OR 16.7 (CI: 2.3-122.2). The rintSO2range was smaller (33% vs. 51%, p < 0.01) and I-FABPu was higher (92.4 vs. 25.5 ng/mL, p = 0.03) in case of post-NEC stricture, but not different in case of recurrent NEC, compared with infants without complications.
CONCLUSION: The rintSO2, its range, and I-FABPu after the first re-feed after NEC predicted intestinal recovery. These biomarkers have potential value in individualizing feeding regimens after NEC.
|Number of pages||7|
|Early online date||24-Oct-2019|
|Publication status||Published - Apr-2020|
- NEAR-INFRARED SPECTROSCOPY, SUPERIOR MESENTERIC-ARTERY, ACID-BINDING PROTEIN, SPLANCHNIC OXYGENATION, INTERNATIONAL SURVEY, TISSUE OXYGENATION, ISCHEMIA, RISK, MANAGEMENT, DIAGNOSIS