Publication

Preconception environmental factors and placental morphometry in relation to pregnancy outcome

Salavati, N., 2020, [Groningen]: Rijksuniversiteit Groningen. 249 p.

Research output: ThesisThesis fully internal (DIV)Academic

Copy link to clipboard

Documents

  • Title and contents

    Final publisher's version, 1 MB, PDF document

  • Chapter 1

    Final publisher's version, 184 KB, PDF document

  • Chapter 2

    Final publisher's version, 260 KB, PDF document

  • Chapter 3

    Final publisher's version, 386 KB, PDF document

  • Chapter 4

    Final publisher's version, 455 KB, PDF document

    Embargo ends: 27/01/2021

  • Chapter 5

    Final publisher's version, 227 KB, PDF document

    Embargo ends: 27/01/2021

  • Chapter 6

    Final publisher's version, 951 KB, PDF document

  • Chapter 7

    Final publisher's version, 1 MB, PDF document

  • Chapter 8

    Final publisher's version, 348 KB, PDF document

  • Chapter 9

    Final publisher's version, 331 KB, PDF document

  • Appendices

    Final publisher's version, 203 KB, PDF document

  • Complete thesis

    Final publisher's version, 14 MB, PDF document

    Embargo ends: 27/01/2021

  • Propositions

    Final publisher's version, 426 KB, PDF document

DOI

In this thesis, the relation between both preconception environmental factors (including air pollution, and maternal dietary intake) and that of placental morphometry with pregnancy outcome was investigated.
It has been quite well established that maternal dietary intake during pregnancy is associated with pregnancy outcome. However, during the past few years there is increased recognition that maternal dietary intake already from preconception onwards may affect pregnancy outcome. Literature investigating this association is still scarce. Therefore we created the ‘Perined-Lifelines birth cohort’ by linking the Dutch national birth registry (Perined) with a large population-based cohort study (The Lifelines Cohort study) through a ‘trusted third party’ with the aim to provide insights on the associations between maternal dietary intake before conception and pregnancy outcome. Within this birth cohort we observed that maternal dietary intake during preconception was associated with birth weight of the offspring. Interestingly, specifically within the group of women with the lowest BMI in our cohort, higher intake of specific macronutrients was associated with increased birth weight of their offspring. We recommend that any dietary assessment and advise during preconception should be customized to preconception weight status of the women.

Secondly, we demonstrated that both ultrasonic fetal biometry and Doppler flow velocimetry are associated with placental morphometry after birth. In addition, the possible use of placental morhometry in detection of fetal growth restriction was investigated. Parameters such as placental surface area, placental volume in relation to birth weight can help to identify newborns who might have encountered fetal growth restriction and need accurate monitoring after birth.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
Award date27-Jan-2020
Place of Publication[Groningen]
Publisher
Print ISBNs978-94-6375-696-9
Publication statusPublished - 2020

Download statistics

No data available

ID: 109922073