Publication
Preclinical targeting of the tumor microenvironment: Possibilities and consequences
Arjaans, M., 2015, [Groningen]: University of Groningen. 150 p.Research output: Thesis › Thesis fully internal (DIV)

Documents
- Title and contents
Final publisher's version, 186 KB, PDF document
- Chapter 1
Final publisher's version, 222 KB, PDF document
- Chapter 2
Final publisher's version, 5.52 MB, PDF document
- Chapter 3
Final publisher's version, 4.73 MB, PDF document
- Chapter 4
Final publisher's version, 2.4 MB, PDF document
- Chapter 5A
Final publisher's version, 3.41 MB, PDF document
- Chapter 5B
Final publisher's version, 226 KB, PDF document
- Chapter 6
Final publisher's version, 392 KB, PDF document
- Chapter 7
Final publisher's version, 286 KB, PDF document
- Chapter 8
Final publisher's version, 254 KB, PDF document
- Acknowledgements
Final publisher's version, 227 KB, PDF document
- Complete dissertation
Final publisher's version, 15.7 MB, PDF document
- Propositions
Final publisher's version, 123 KB, PDF document
The tumor and its microenvironment are reproduced in preclinical models consisting of both stromal and cancer cells. These in vitro and in vivo models show that stromal cells are needed to exert the TGF-β mediated anti-breast cancer effect of the bisphosphonate zoledronic acid. In addition, the preclinical development of a TGF-β tracer is described. With this technique, a radiolabeled antibody can be depicted with the help of positron emission tomography (PET). With the use of the TGF-β tracer it was possible to portray the presence of TGF-β in tumors.
For VEGF, the effect of anti-VEGF therapy on tumor uptake of drugs was evaluated with the help of PET imaging. Anti-VEGF therapy reduced tumor uptake of other drugs in two preclinical models.
In conclusion, this thesis describes the possibilities and consequences of targeting factors present in the tumor microenvironment.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution | |
Supervisors/Advisors |
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Award date | 15-Apr-2015 |
Place of Publication | [Groningen] |
Publisher | |
Publication status | Published - 2015 |
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