Pre- and Post-analytical Factors in Biomarker DiscoveryKlont, F., Horvatovich, P., Govorukhina, N. & Bischoff, R., 11-Mar-2019, Proteomics for Biomarker Discovery. Brun, V. & Couté, Y. (eds.). Humana Press, p. 1-22 22 p. (Methods in Molecular Biology; vol. 1959).
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
The translation of promising biomarkers, which were identified in biomarker discovery experiments, to clinical assays is one of the key challenges in present-day proteomics research. Many so-called "biomarker candidates" fail to progress beyond the discovery phase, and much emphasis is placed on pre- and post-analytical variability in an attempt to provide explanations for this bottleneck in the biomarker development pipeline. With respect to such variability, there is a large number of pre- and post-analytical factors which may impact the outcomes of proteomics experiments and thus necessitate tight control. This chapter highlights some of these factors and provides guidance for addressing them on the basis of examples from previously published proteomics studies.
|Title of host publication||Proteomics for Biomarker Discovery|
|Editors||V. Brun , Y. Couté|
|Number of pages||22|
|Publication status||Published - 11-Mar-2019|
|Name||Methods in Molecular Biology|