Pre- and Post-analytical Factors in Biomarker Discovery

Klont, F., Horvatovich, P., Govorukhina, N. & Bischoff, R., 11-Mar-2019, Proteomics for Biomarker Discovery. Brun, V. & Couté, Y. (eds.). Humana Press, p. 1-22 22 p. (Methods in Molecular Biology; vol. 1959).

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The translation of promising biomarkers, which were identified in biomarker discovery experiments, to clinical assays is one of the key challenges in present-day proteomics research. Many so-called "biomarker candidates" fail to progress beyond the discovery phase, and much emphasis is placed on pre- and post-analytical variability in an attempt to provide explanations for this bottleneck in the biomarker development pipeline. With respect to such variability, there is a large number of pre- and post-analytical factors which may impact the outcomes of proteomics experiments and thus necessitate tight control. This chapter highlights some of these factors and provides guidance for addressing them on the basis of examples from previously published proteomics studies.

Original languageEnglish
Title of host publicationProteomics for Biomarker Discovery
EditorsV. Brun , Y. Couté
PublisherHumana Press
Number of pages22
ISBN (Electronic)978-1-4939-9164-8
ISBN (Print)978-1-4939-9163-1
Publication statusPublished - 11-Mar-2019

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745

ID: 77492845