Publication

Potential Red-Flag Identification of Colorectal Adenomas with Wide-Field Fluorescence Molecular Endoscopy

Hartmans, E., Tjalma, J. J. J., Linssen, M. D., Allende, P. B. G., Koller, M., Jorritsma-Smit, A., Nery, M. E. S. D. O., Elias, S. G., Karrenbeld, A., de Vries, E. G. E., Kleibeuker, J. H., van Dam, G. M., Robinson, D. J., Ntziachristos, V. & Nagengast, W. B., 5-Feb-2018, In : Theranostics. 8, 6, p. 1458-1467 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated adenomas/polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch syndrome. Detection rates may be improved by fluorescence molecular endoscopy (FME), which allows morphological visualization of lesions with high-definition white-light imaging as well as fluorescence-guided identification of lesions with a specific molecular marker. In a clinical proof-of-principal study, we investigated FME for colorectal adenoma detection, using a fluorescently labelled antibody (bevacizumab-800CW) against vascular endothelial growth factor A (VEGFA), which is highly upregulated in colorectal adenomas.

Methods: Patients with familial adenomatous polyposis (n = 17), received an intravenous injection with 4.5, 10 or 25 mg of bevacizumab-800CW. Three days later, they received NIR-FME.

Results: VEGFA-targeted NIR-FME detected colorectal adenomas at all doses. Best results were achieved in the highest (25 mg) cohort, which even detected small adenomas (

Conclusion: These results suggest that NIR-FME is clinically feasible as a real-time, red-flag technique for detection of colorectal adenomas.

Original languageEnglish
Pages (from-to)1458-1467
Number of pages10
JournalTheranostics
Volume8
Issue number6
Publication statusPublished - 5-Feb-2018

    Keywords

  • optical molecular imaging, spectroscopy, vascular endothelial growth factor a, near-infrared fluorescence, GROWTH-FACTOR RECEPTOR, COLONOSCOPIC SURVEILLANCE, LYNCH-SYNDROME, CANCER, DIAGNOSIS, LESIONS

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