Publication

Positron Emission Tomography (PET) Imaging of Opioid Receptors

van Waarde, A., Absalom, A., Visser, A. & Dierckx, R., 2014, PET and SPECT of Neurobiological Systems. Dierckx, R. AJO., Otte, A., De Vries, E. FJ., Van Waarde, A. & Luiten, P. GM. (eds.). Heidelberg: Springer, p. 585-624 40 p. 20

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

APA

van Waarde, A., Absalom, A., Visser, A., & Dierckx, R. (2014). Positron Emission Tomography (PET) Imaging of Opioid Receptors. In R. AJO. Dierckx, A. Otte, E. FJ. De Vries, A. Van Waarde, & P. GM. Luiten (Eds.), PET and SPECT of Neurobiological Systems (pp. 585-624). [20] Heidelberg: Springer. https://doi.org/10.1007/978-3-642-42014-6_20

Author

van Waarde, Aren ; Absalom, Anthony ; Visser, Anniek ; Dierckx, Rudi. / Positron Emission Tomography (PET) Imaging of Opioid Receptors. PET and SPECT of Neurobiological Systems. editor / Rudi AJO Dierckx ; Andreas Otte ; Erik FJ De Vries ; Aren Van Waarde ; Paul GM Luiten. Heidelberg : Springer, 2014. pp. 585-624

Harvard

van Waarde, A, Absalom, A, Visser, A & Dierckx, R 2014, Positron Emission Tomography (PET) Imaging of Opioid Receptors. in RAJO Dierckx, A Otte, EFJ De Vries, A Van Waarde & PGM Luiten (eds), PET and SPECT of Neurobiological Systems., 20, Springer, Heidelberg, pp. 585-624. https://doi.org/10.1007/978-3-642-42014-6_20

Standard

Positron Emission Tomography (PET) Imaging of Opioid Receptors. / van Waarde, Aren; Absalom, Anthony; Visser, Anniek; Dierckx, Rudi.

PET and SPECT of Neurobiological Systems. ed. / Rudi AJO Dierckx; Andreas Otte; Erik FJ De Vries; Aren Van Waarde; Paul GM Luiten. Heidelberg : Springer, 2014. p. 585-624 20.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Vancouver

van Waarde A, Absalom A, Visser A, Dierckx R. Positron Emission Tomography (PET) Imaging of Opioid Receptors. In Dierckx RAJO, Otte A, De Vries EFJ, Van Waarde A, Luiten PGM, editors, PET and SPECT of Neurobiological Systems. Heidelberg: Springer. 2014. p. 585-624. 20 https://doi.org/10.1007/978-3-642-42014-6_20


BibTeX

@inbook{9b8af93c24d2488eb8cc29d90bbfa17a,
title = "Positron Emission Tomography (PET) Imaging of Opioid Receptors",
abstract = "The opioid system consists of opioid receptors (which mediate the actions of opium), their endogenous ligands (the enkephalins, endorphins, endomorphins, dynorphin, and nociceptin), and the proteins involved in opioid production, transport, and degradation. PET tracers for the various opioid receptor subtypes are available, and changes in regional opioidergic activity have been assessed during both sensory and affective processing in healthy individuals and in various disease conditions such as chronic pain, neurodegeneration, epilepsy, eating disorders, and substance abuse. It is not always clear whether observed changes of tracer binding refl ect altered release of endogenous opioids or altered opioid receptor expression. Some radioligands for opioid receptors have suboptimal kinetics (i.e., slow dissociation from their target protein) or can induce undesired side effects even at low administered doses (sedation, respiratory arrest). There remains a need for PET tracers with improved properties, which can selectively visualize changes of the apparent density of a single opioid receptor subtype. Yet, PET offers the unique opportunity of quantifying opioid receptor- mediated signaling in the human central nervous system in vivo.",
keywords = "OPIOID RECEPTORS, POSITRON EMISSION TOMOGRAPHY, radioligands, HUMAN, BRAIN, REVIEW, Radiochemistry",
author = "{van Waarde}, Aren and Anthony Absalom and Anniek Visser and Rudi Dierckx",
year = "2014",
doi = "10.1007/978-3-642-42014-6_20",
language = "English",
isbn = "978-3-642-42013-9",
pages = "585--624",
editor = "Dierckx, {Rudi AJO} and Andreas Otte and {De Vries}, {Erik FJ} and {Van Waarde}, Aren and Luiten, {Paul GM}",
booktitle = "PET and SPECT of Neurobiological Systems",
publisher = "Springer",

}

RIS

TY - CHAP

T1 - Positron Emission Tomography (PET) Imaging of Opioid Receptors

AU - van Waarde, Aren

AU - Absalom, Anthony

AU - Visser, Anniek

AU - Dierckx, Rudi

PY - 2014

Y1 - 2014

N2 - The opioid system consists of opioid receptors (which mediate the actions of opium), their endogenous ligands (the enkephalins, endorphins, endomorphins, dynorphin, and nociceptin), and the proteins involved in opioid production, transport, and degradation. PET tracers for the various opioid receptor subtypes are available, and changes in regional opioidergic activity have been assessed during both sensory and affective processing in healthy individuals and in various disease conditions such as chronic pain, neurodegeneration, epilepsy, eating disorders, and substance abuse. It is not always clear whether observed changes of tracer binding refl ect altered release of endogenous opioids or altered opioid receptor expression. Some radioligands for opioid receptors have suboptimal kinetics (i.e., slow dissociation from their target protein) or can induce undesired side effects even at low administered doses (sedation, respiratory arrest). There remains a need for PET tracers with improved properties, which can selectively visualize changes of the apparent density of a single opioid receptor subtype. Yet, PET offers the unique opportunity of quantifying opioid receptor- mediated signaling in the human central nervous system in vivo.

AB - The opioid system consists of opioid receptors (which mediate the actions of opium), their endogenous ligands (the enkephalins, endorphins, endomorphins, dynorphin, and nociceptin), and the proteins involved in opioid production, transport, and degradation. PET tracers for the various opioid receptor subtypes are available, and changes in regional opioidergic activity have been assessed during both sensory and affective processing in healthy individuals and in various disease conditions such as chronic pain, neurodegeneration, epilepsy, eating disorders, and substance abuse. It is not always clear whether observed changes of tracer binding refl ect altered release of endogenous opioids or altered opioid receptor expression. Some radioligands for opioid receptors have suboptimal kinetics (i.e., slow dissociation from their target protein) or can induce undesired side effects even at low administered doses (sedation, respiratory arrest). There remains a need for PET tracers with improved properties, which can selectively visualize changes of the apparent density of a single opioid receptor subtype. Yet, PET offers the unique opportunity of quantifying opioid receptor- mediated signaling in the human central nervous system in vivo.

KW - OPIOID RECEPTORS

KW - POSITRON EMISSION TOMOGRAPHY

KW - radioligands

KW - HUMAN

KW - BRAIN

KW - REVIEW

KW - Radiochemistry

U2 - 10.1007/978-3-642-42014-6_20

DO - 10.1007/978-3-642-42014-6_20

M3 - Chapter

SN - 978-3-642-42013-9

SP - 585

EP - 624

BT - PET and SPECT of Neurobiological Systems

A2 - Dierckx, Rudi AJO

A2 - Otte, Andreas

A2 - De Vries, Erik FJ

A2 - Van Waarde, Aren

A2 - Luiten, Paul GM

PB - Springer

CY - Heidelberg

ER -

ID: 15998080