Publication

Positron Emission Tomography (PET) Imaging of Opioid Receptors

van Waarde, A., Absalom, A., Visser, A. & Dierckx, R., 2014, PET and SPECT of Neurobiological Systems. Dierckx, R. AJO., Otte, A., De Vries, E. FJ., Van Waarde, A. & Luiten, P. GM. (eds.). Heidelberg: Springer, p. 585-624 40 p. 20

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

The opioid system consists of opioid receptors (which mediate the actions of
opium), their endogenous ligands (the enkephalins, endorphins, endomorphins,
dynorphin, and nociceptin), and the proteins involved in opioid production,
transport, and degradation. PET tracers for the various opioid receptor subtypes
are available, and changes in regional opioidergic activity have been assessed
during both sensory and affective processing in healthy individuals and in various
disease conditions such as chronic pain, neurodegeneration, epilepsy, eating
disorders, and substance abuse. It is not always clear whether observed changes
of tracer binding refl ect altered release of endogenous opioids or altered opioid
receptor expression. Some radioligands for opioid receptors have suboptimal
kinetics (i.e., slow dissociation from their target protein) or can induce undesired
side effects even at low administered doses (sedation, respiratory arrest). There
remains a need for PET tracers with improved properties, which can selectively
visualize changes of the apparent density of a single opioid receptor subtype.
Yet, PET offers the unique opportunity of quantifying opioid receptor- mediated
signaling in the human central nervous system in vivo.
Original languageEnglish
Title of host publicationPET and SPECT of Neurobiological Systems
EditorsRudi AJO Dierckx, Andreas Otte, Erik FJ De Vries, Aren Van Waarde, Paul GM Luiten
Place of PublicationHeidelberg
PublisherSpringer
Pages585-624
Number of pages40
ISBN (Electronic)978-3-642-42014-6
ISBN (Print)978-3-642-42013-9
Publication statusPublished - 2014

    Keywords

  • OPIOID RECEPTORS, POSITRON EMISSION TOMOGRAPHY, radioligands, HUMAN, BRAIN, REVIEW, Radiochemistry

ID: 15998080