Publication

Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery

Fitzgerald, S. P., Beverborg, N. G., Beguin, Y., Artunc, F., Falhammar, H. & Bean, N. G., Jun-2019, In : Physiological Reports. 7, 12, 10 p., 14153.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Fitzgerald, S. P., Beverborg, N. G., Beguin, Y., Artunc, F., Falhammar, H., & Bean, N. G. (2019). Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery. Physiological Reports, 7(12), [14153]. https://doi.org/10.14814/phy2.14153

Author

Fitzgerald, Stephen P. ; Beverborg, Niels Grote ; Beguin, Yves ; Artunc, Ferruh ; Falhammar, Henrik ; Bean, Nigel G. / Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery. In: Physiological Reports. 2019 ; Vol. 7, No. 12.

Harvard

Fitzgerald, SP, Beverborg, NG, Beguin, Y, Artunc, F, Falhammar, H & Bean, NG 2019, 'Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery', Physiological Reports, vol. 7, no. 12, 14153. https://doi.org/10.14814/phy2.14153

Standard

Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery. / Fitzgerald, Stephen P.; Beverborg, Niels Grote; Beguin, Yves; Artunc, Ferruh; Falhammar, Henrik; Bean, Nigel G.

In: Physiological Reports, Vol. 7, No. 12, 14153, 06.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Fitzgerald SP, Beverborg NG, Beguin Y, Artunc F, Falhammar H, Bean NG. Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery. Physiological Reports. 2019 Jun;7(12). 14153. https://doi.org/10.14814/phy2.14153


BibTeX

@article{86761780b5804269a6581ba0100c616f,
title = "Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery",
abstract = "Hemoglobin levels are believed to be regulated as per a set point model of regulation. This model of regulation, by which specific levels of a parameter are targeted and defended by physiological systems, implies a particular population correlation between the parameter and its controlling hormone. Empirical population correlations of other parameters and their controlling hormones, have denied the presence of such set point-based regulation. To assess if hemoglobin is regulated according to a set point model we performed a systematic search of PubMed/MEDLINE and Web of Science identifying relevant reports published up to November 2018. Population hemoglobin/erythropoietin level correlations were retrieved, and these empirically derived correlations were compared with the positive correlation implied by a set point model of regulation. Authors of papers containing potentially suitable data were contacted with requests for further analyses, and a meta-analysis was performed. Twelve correlations between hemoglobin and erythropoietin levels from eleven papers were analyzed. None of these correlations were significantly positive, three, restricted to the normal range of hemoglobin, were significantly negative. All but one of the other correlations showed a negative trend. New analyses of previously published data sets resulted in similar findings. In particular a new analysis of large data sets of males (n = 2417) and females (n = 2592) with normal range hemoglobin levels, revealed significantly negative correlations. A meta-analysis of our results indicated that the data overall are not consistent with a positive relationship between hemoglobin and erythropoietin (P <0.0001). Population data indicate that individuals do not have set point levels of hemoglobin.",
keywords = "Erythropoietin, haemoglobin, population correlations, set point, ERYTHROPOIETIN LEVELS, SERUM ERYTHROPOIETIN, TRANSFERRIN RECEPTOR, ANEMIA",
author = "Fitzgerald, {Stephen P.} and Beverborg, {Niels Grote} and Yves Beguin and Ferruh Artunc and Henrik Falhammar and Bean, {Nigel G.}",
year = "2019",
month = "6",
doi = "10.14814/phy2.14153",
language = "English",
volume = "7",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "Wiley",
number = "12",

}

RIS

TY - JOUR

T1 - Population data provide evidence against the presence of a set point for hemoglobin levels or tissue oxygen delivery

AU - Fitzgerald, Stephen P.

AU - Beverborg, Niels Grote

AU - Beguin, Yves

AU - Artunc, Ferruh

AU - Falhammar, Henrik

AU - Bean, Nigel G.

PY - 2019/6

Y1 - 2019/6

N2 - Hemoglobin levels are believed to be regulated as per a set point model of regulation. This model of regulation, by which specific levels of a parameter are targeted and defended by physiological systems, implies a particular population correlation between the parameter and its controlling hormone. Empirical population correlations of other parameters and their controlling hormones, have denied the presence of such set point-based regulation. To assess if hemoglobin is regulated according to a set point model we performed a systematic search of PubMed/MEDLINE and Web of Science identifying relevant reports published up to November 2018. Population hemoglobin/erythropoietin level correlations were retrieved, and these empirically derived correlations were compared with the positive correlation implied by a set point model of regulation. Authors of papers containing potentially suitable data were contacted with requests for further analyses, and a meta-analysis was performed. Twelve correlations between hemoglobin and erythropoietin levels from eleven papers were analyzed. None of these correlations were significantly positive, three, restricted to the normal range of hemoglobin, were significantly negative. All but one of the other correlations showed a negative trend. New analyses of previously published data sets resulted in similar findings. In particular a new analysis of large data sets of males (n = 2417) and females (n = 2592) with normal range hemoglobin levels, revealed significantly negative correlations. A meta-analysis of our results indicated that the data overall are not consistent with a positive relationship between hemoglobin and erythropoietin (P <0.0001). Population data indicate that individuals do not have set point levels of hemoglobin.

AB - Hemoglobin levels are believed to be regulated as per a set point model of regulation. This model of regulation, by which specific levels of a parameter are targeted and defended by physiological systems, implies a particular population correlation between the parameter and its controlling hormone. Empirical population correlations of other parameters and their controlling hormones, have denied the presence of such set point-based regulation. To assess if hemoglobin is regulated according to a set point model we performed a systematic search of PubMed/MEDLINE and Web of Science identifying relevant reports published up to November 2018. Population hemoglobin/erythropoietin level correlations were retrieved, and these empirically derived correlations were compared with the positive correlation implied by a set point model of regulation. Authors of papers containing potentially suitable data were contacted with requests for further analyses, and a meta-analysis was performed. Twelve correlations between hemoglobin and erythropoietin levels from eleven papers were analyzed. None of these correlations were significantly positive, three, restricted to the normal range of hemoglobin, were significantly negative. All but one of the other correlations showed a negative trend. New analyses of previously published data sets resulted in similar findings. In particular a new analysis of large data sets of males (n = 2417) and females (n = 2592) with normal range hemoglobin levels, revealed significantly negative correlations. A meta-analysis of our results indicated that the data overall are not consistent with a positive relationship between hemoglobin and erythropoietin (P <0.0001). Population data indicate that individuals do not have set point levels of hemoglobin.

KW - Erythropoietin

KW - haemoglobin

KW - population correlations

KW - set point

KW - ERYTHROPOIETIN LEVELS

KW - SERUM ERYTHROPOIETIN

KW - TRANSFERRIN RECEPTOR

KW - ANEMIA

U2 - 10.14814/phy2.14153

DO - 10.14814/phy2.14153

M3 - Article

VL - 7

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 12

M1 - 14153

ER -

ID: 93766447