Publication

Polycystic ovary syndrome and early-onset preeclampsia: reproductive manifestations of increased cardiovascular risk

Veltman-Verhulst, S. M., van Rijn, B. B., Westerveld, H. E., Franx, A., Bruinse, H. W., Fauser, B. C. J. M. & Goverde, A. J., 2010, In : Menopause-the Journal of the North American Menopause Society. 17, 5, p. 990-996 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Susanne M. Veltman-Verhulst
  • Bas B. van Rijn
  • H. Egbertine Westerveld
  • Arie Franx
  • Hein W. Bruinse
  • Bart C. J. M. Fauser
  • Angelique J. Goverde

Objective: Primary prevention of cardiovascular disease (CVD) in women is a major healthcare issue. Detection of premenopausal women with increased risk of CVD could enhance prevention strategies and reduce first event-related morbidity and mortality. In this study, we argue that an unfavorable metabolic constitution in women may present itself early in life as a reproductive complication, such as polycystic ovary syndrome (PCOS) and preeclampsia. We evaluated the cardiovascular risk of women with a history of early-onset preeclampsia and women with PCOS and assessed their need for implementation of early risk factor-reduction strategies.

Methods: We performed a standardized evaluation of 240 women with a history of early-onset preeclampsia and 456 women diagnosed with PCOS for established major CVD risk factors. Metabolic syndrome characteristics were analyzed per body mass index category.

Results: Mean age was 30.6 and 29.0 years for women with preeclampsia and PCOS, respectively. High percentages of metabolic syndrome were found in both groups (preeclampsia group, 14.6%; and PCOS group, 18.4%), with an incidence of greater than 50% in both groups of women if body mass index was greater than 30 kg/m(2). Overall, more than 90% of the women qualified for either lifestyle or medical intervention according to the American Heart Association guideline for CVD prevention in women.

Conclusions: Women with PCOS and early-onset preeclampsia already show an unfavorable cardiovascular risk profile with high need for lifestyle or medical intervention at a young age. We therefore recommend an active role of the gynecologist in routine screening and follow-up of women with reproductive conditions linked to future cardiovascular risk.

Original languageEnglish
Pages (from-to)990-996
Number of pages7
JournalMenopause-the Journal of the North American Menopause Society
Volume17
Issue number5
Publication statusPublished - 2010

    Keywords

  • Polycystic ovary syndrome, Preeclampsia, Women, Cardiovascular disease, Prevention, CORONARY-HEART-DISEASE, INTRAUTERINE GROWTH RESTRICTION, METABOLIC SYNDROME, YOUNG-ADULTS, ATHEROSCLEROSIS RISK, DIAGNOSTIC-CRITERIA, WAIST CIRCUMFERENCE, INSULIN-RESISTANCE, PRIMARY PREVENTION, WOMEN

ID: 5158434