Publication
Poly(beta-Amino Esters): Synthesis, Formulations, and Their Biomedical Applications
Liu, Y., Li, Y., Keskin, D. & Shi, L., 24-Jan-2019, In : Advanced healthcare materials. 8, 2, 24 p., 1801359.Research output: Contribution to journal › Review article › Academic › peer-review

Documents
- Poly(β‐Amino Esters): Synthesis, Formulations, and Their Biomedical Applications
Final publisher's version, 4.94 MB, PDF document
DOI
Poly(beta-amino ester) (abbreviated as PBAE or PAE) refers to a polymer synthesized from an acrylate and an amine by Michael addition and has properties inherent to tertiary amines and esters, such as pH responsiveness and biodegradability. The versatility of building blocks provides a library of polymers with miscellaneous physicochemical and mechanical properties. When used alone or together with other materials, PBAEs can be fabricated into different formulations in order to fulfill various requirements in drug delivery (for instance, gene, anticancer drugs, and antimicrobials delivery) and natural complex mimicry (nanochaperones). This progress report discusses the recent developments in design, synthesis, formulations, and applications of PBAEs in biomedical fields and provides a perspective view for the future of the PBAEs.
Original language | English |
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Article number | 1801359 |
Number of pages | 24 |
Journal | Advanced healthcare materials |
Volume | 8 |
Issue number | 2 |
Publication status | Published - 24-Jan-2019 |
- artificial chaperones, cancer therapy, drug delivery, infection control, poly(beta-amino ester), BLOCK-COPOLYMER MICELLES, SENSITIVE POLYMERIC NANOPARTICLES, OVERCOMING MULTIDRUG-RESISTANCE, BIODEGRADABLE DNA NANOPARTICLES, GENE DELIVERY NANOPARTICLES, CO-DELIVERY, DRUG-DELIVERY, CONTROLLED-RELEASE, MOLECULAR-WEIGHT, CIRCULATION TIME
Keywords
ID: 91013085