Publication

Platelets as Modulators of Liver Diseases

Lisman, T. & Luyendyk, J. P., Mar-2018, In : Seminars in thrombosis and hemostasis. 44, 2, p. 114-125 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Platelets are key players in thrombosis and hemostasis. Alterations in platelet count and function are common in liver disease, and may contribute to bleeding or thrombotic complications in liver diseases and during liver surgery. In addition to their hemostatic function, platelets may modulate liver diseases by mechanisms that are incompletely understood. Here, we present clinical evidence for a role of platelets in the progression of chronic and acute liver diseases, including cirrhosis, acute liver failure, and hepatocellular carcinoma. We also present clinical evidence that platelets promote liver regeneration following partial liver resection. Subsequently, we summarize studies in experimental animal models that support these clinical observations, and also highlight studies that are in contrast with clinical observations. The combined results of clinical and experimental studies suggest that platelets may be a therapeutic target in the treatment of liver injury and repair, but the gaps in our understanding of mechanisms involved in platelet-mediated modulation of liver diseases call for caution in clinical application of these findings.

Original languageEnglish
Pages (from-to)114-125
Number of pages12
JournalSeminars in thrombosis and hemostasis
Volume44
Issue number2
Publication statusPublished - Mar-2018

    Keywords

  • platelet, liver cirrhosis, regeneration, inflammation, VON-WILLEBRAND-FACTOR, RANDOMIZED CONTROLLED-TRIALS, CRITICALLY-ILL PATIENTS, HEPATOCELLULAR-CARCINOMA, CIRRHOTIC-PATIENTS, PARANEOPLASTIC THROMBOCYTOSIS, HEPATOCYTE PROLIFERATION, 90-PERCENT HEPATECTOMY, REBALANCED HEMOSTASIS, ANTIPLATELET THERAPY

ID: 65015952