Publication

Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease

Lisman, T., Mar-2018, In : Cell and Tissue Research. 371, 3, p. 567-576 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Neutrophils are well known for their role in infection and inflammatory disease and are first responders at sites of infection or injury. Platelets have an established role in hemostasis and thrombosis and are first responders at sites of vascular damage. However, neutrophils are increasingly recognized for their role in thrombosis, while the immunemodulatory properties of platelets are being increasingly studied. Platelets and neutrophils interact during infection, inflammation and thrombosis and modulate each other's functions. This review will discuss the consequences of platelet-neutrophil interactions in infection, thrombosis, atherosclerosis and tissue injury and repair.

Original languageEnglish
Pages (from-to)567-576
Number of pages10
JournalCell and Tissue Research
Volume371
Issue number3
Publication statusPublished - Mar-2018

    Keywords

  • Platelet, Neutrophil, Inflammation, Thrombosis, Ischemia, ISCHEMIA-REPERFUSION INJURY, VON-WILLEBRAND-FACTOR, DEEP-VEIN THROMBOSIS, MURINE ACETAMINOPHEN HEPATOTOXICITY, PROTEASE-ACTIVATED RECEPTOR-4, EXTRACELLULAR TRAP FORMATION, TISSUE FACTOR EXPRESSION, ACUTE CORONARY SYNDROME, IMPAIRS HOST-DEFENSE, INDUCED LIVER-INJURY

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