Publication

Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study

Scholtens, R. M., van Munster, B. C., van Faassen, M., van Kempen, M. F., Kema, I. P. & de Rooij, S. E., Oct-2017, In : Mechanisms of Ageing and Development. 167, p. 1-4 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Scholtens, R. M., van Munster, B. C., van Faassen, M., van Kempen, M. F., Kema, I. P., & de Rooij, S. E. (2017). Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. Mechanisms of Ageing and Development, 167, 1-4. https://doi.org/10.1016/j.mad.2017.08.016

Author

Scholtens, Rikie M. ; van Munster, Barbara C. ; van Faassen, Martijn ; van Kempen, Marijn F. ; Kema, Ido P. ; de Rooij, Sophia E. / Plasma melatonin levels in hip fracture patients with and without delirium : A confirmation study. In: Mechanisms of Ageing and Development. 2017 ; Vol. 167. pp. 1-4.

Harvard

Scholtens, RM, van Munster, BC, van Faassen, M, van Kempen, MF, Kema, IP & de Rooij, SE 2017, 'Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study', Mechanisms of Ageing and Development, vol. 167, pp. 1-4. https://doi.org/10.1016/j.mad.2017.08.016

Standard

Plasma melatonin levels in hip fracture patients with and without delirium : A confirmation study. / Scholtens, Rikie M.; van Munster, Barbara C.; van Faassen, Martijn; van Kempen, Marijn F.; Kema, Ido P.; de Rooij, Sophia E.

In: Mechanisms of Ageing and Development, Vol. 167, 10.2017, p. 1-4.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Scholtens RM, van Munster BC, van Faassen M, van Kempen MF, Kema IP, de Rooij SE. Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study. Mechanisms of Ageing and Development. 2017 Oct;167:1-4. https://doi.org/10.1016/j.mad.2017.08.016


BibTeX

@article{e50e8ce4fd2949c783a657d20c9ff03a,
title = "Plasma melatonin levels in hip fracture patients with and without delirium: A confirmation study",
abstract = "Background: Melatonin plays a major role in maintaining circadian rhythm. Changes in melatonin metabolism might lead to circadian rhythm disturbances which are often observed in delirious patients.Aim: To assess if high morning plasma melatonin concentrations were associated with delirium.Methods: Consecutive hip fracture patients aged >= 65 years were included. Delirium was assessed daily with the Confusion AssessmentMethod: Blood samples were collected at 11.00am on weekdays during first week of hospitalization. Melatonin was analyzed by liquid chromatography-tandem mass spectrometry.Results: We analyzed 389 samples of 144 participants [mean age 84.0, 70 experienced delirium]. A Generalized Estimating Equations (GEE) model with outcome melatonin level in highest tertile (> 3.36 pg/ml) and covariates delirium group (i.e. never, before, during, post delirium), cognitive impairment, age, sex and anesthesia type, was constructed. Highest melatonin levels were associated with postoperative samples (Odds Ratio(OR) 2.11 compared to preoperative samples; 95% Confidence Interval(CI) 1.17-3.82, p = 0.01) and higher age (OR 1.05 per year; Cl 1.01-1.11, p = 0.03), but not with delirium group(p = 0.35).Conclusion: Undergoing surgery and aging in general may induce changes in melatonin metabolism. Future research should focus on daily multiple melatonin measurements to determine whether melatonin supplementation might be beneficial for delirium treatment or prevention.",
keywords = "Delirium, Melatonin, Circadian rhythm, Hip fracture, Aged, Elderly, ELDERLY-PATIENTS, SERUM MELATONIN, POSTOPERATIVE DELIRIUM, CIRCADIAN-RHYTHM, ALZHEIMERS TYPE, DEMENTIA, SECRETION, SURGERY, AGE",
author = "Scholtens, {Rikie M.} and {van Munster}, {Barbara C.} and {van Faassen}, Martijn and {van Kempen}, {Marijn F.} and Kema, {Ido P.} and {de Rooij}, {Sophia E.}",
year = "2017",
month = oct,
doi = "10.1016/j.mad.2017.08.016",
language = "English",
volume = "167",
pages = "1--4",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "ELSEVIER IRELAND LTD",

}

RIS

TY - JOUR

T1 - Plasma melatonin levels in hip fracture patients with and without delirium

T2 - A confirmation study

AU - Scholtens, Rikie M.

AU - van Munster, Barbara C.

AU - van Faassen, Martijn

AU - van Kempen, Marijn F.

AU - Kema, Ido P.

AU - de Rooij, Sophia E.

PY - 2017/10

Y1 - 2017/10

N2 - Background: Melatonin plays a major role in maintaining circadian rhythm. Changes in melatonin metabolism might lead to circadian rhythm disturbances which are often observed in delirious patients.Aim: To assess if high morning plasma melatonin concentrations were associated with delirium.Methods: Consecutive hip fracture patients aged >= 65 years were included. Delirium was assessed daily with the Confusion AssessmentMethod: Blood samples were collected at 11.00am on weekdays during first week of hospitalization. Melatonin was analyzed by liquid chromatography-tandem mass spectrometry.Results: We analyzed 389 samples of 144 participants [mean age 84.0, 70 experienced delirium]. A Generalized Estimating Equations (GEE) model with outcome melatonin level in highest tertile (> 3.36 pg/ml) and covariates delirium group (i.e. never, before, during, post delirium), cognitive impairment, age, sex and anesthesia type, was constructed. Highest melatonin levels were associated with postoperative samples (Odds Ratio(OR) 2.11 compared to preoperative samples; 95% Confidence Interval(CI) 1.17-3.82, p = 0.01) and higher age (OR 1.05 per year; Cl 1.01-1.11, p = 0.03), but not with delirium group(p = 0.35).Conclusion: Undergoing surgery and aging in general may induce changes in melatonin metabolism. Future research should focus on daily multiple melatonin measurements to determine whether melatonin supplementation might be beneficial for delirium treatment or prevention.

AB - Background: Melatonin plays a major role in maintaining circadian rhythm. Changes in melatonin metabolism might lead to circadian rhythm disturbances which are often observed in delirious patients.Aim: To assess if high morning plasma melatonin concentrations were associated with delirium.Methods: Consecutive hip fracture patients aged >= 65 years were included. Delirium was assessed daily with the Confusion AssessmentMethod: Blood samples were collected at 11.00am on weekdays during first week of hospitalization. Melatonin was analyzed by liquid chromatography-tandem mass spectrometry.Results: We analyzed 389 samples of 144 participants [mean age 84.0, 70 experienced delirium]. A Generalized Estimating Equations (GEE) model with outcome melatonin level in highest tertile (> 3.36 pg/ml) and covariates delirium group (i.e. never, before, during, post delirium), cognitive impairment, age, sex and anesthesia type, was constructed. Highest melatonin levels were associated with postoperative samples (Odds Ratio(OR) 2.11 compared to preoperative samples; 95% Confidence Interval(CI) 1.17-3.82, p = 0.01) and higher age (OR 1.05 per year; Cl 1.01-1.11, p = 0.03), but not with delirium group(p = 0.35).Conclusion: Undergoing surgery and aging in general may induce changes in melatonin metabolism. Future research should focus on daily multiple melatonin measurements to determine whether melatonin supplementation might be beneficial for delirium treatment or prevention.

KW - Delirium

KW - Melatonin

KW - Circadian rhythm

KW - Hip fracture

KW - Aged

KW - Elderly

KW - ELDERLY-PATIENTS

KW - SERUM MELATONIN

KW - POSTOPERATIVE DELIRIUM

KW - CIRCADIAN-RHYTHM

KW - ALZHEIMERS TYPE

KW - DEMENTIA

KW - SECRETION

KW - SURGERY

KW - AGE

U2 - 10.1016/j.mad.2017.08.016

DO - 10.1016/j.mad.2017.08.016

M3 - Article

VL - 167

SP - 1

EP - 4

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

ER -

ID: 49937436