Publication

Plasma Malondialdehyde and Risk of New-Onset Diabetes after Transplantation in Renal Transplant Recipients: A Prospective Cohort Study

Yepes-Calderon, M., Sotomayor, C. G., Gomes-Neto, A. W., Gans, R. O. B., Berger, S. P., Rimbach, G., Esatbeyoglu, T., Rodrigo, R., Geleijnse, J. M., Navis, G. J. & Bakker, S. J. L., Apr-2019, In : Journal of Clinical Medicine. 8, 4, 12 p., 453.

Research output: Contribution to journalArticleAcademicpeer-review

New-onset diabetes after transplantation (NODAT) is a frequent complication in renal transplant recipients (RTR). Although oxidative stress has been associated with diabetes mellitus, data regarding NODAT are limited. We aimed to prospectively investigate the long-term association between the oxidative stress biomarker malondialdehyde (measured by high-performance liquid chromatography) and NODAT in an extensively phenotyped cohort of non-diabetic RTR with a functioning graft 1 year. We included 516 RTR (51 +/- 13 years-old, 57% male). Median plasma malondialdehyde (MDA) was 2.55 (IQR, 1.92-3.66) mu mol/L. During a median follow-up of 5.3 (IQR, 4.6-6.0) years, 56 (11%) RTR developed NODAT. In Cox proportional-hazards regression analyses, MDA was inversely associated with NODAT, independent of immunosuppressive therapy, transplant-specific covariates, lifestyle, inflammation, and metabolism parameters (HR, 0.55; 95% CI, 0.36-0.83 per 1-SD increase; p <0.01). Dietary antioxidants intake (e.g., vitamin E, -lipoic acid, and linoleic acid) were effect-modifiers of the association between MDA and NODAT, with particularly strong inverse associations within the subgroup of RTR with relatively higher dietary antioxidants intake. In conclusion, plasma MDA concentration is inversely and independently associated with long-term risk of NODAT in RTR. Our findings support a potential underrecognized role of oxidative stress in post-transplantation glucose homeostasis.

Original languageEnglish
Article number453
Number of pages12
JournalJournal of Clinical Medicine
Volume8
Issue number4
Publication statusPublished - Apr-2019

    Keywords

  • malondialdehyde, oxidative stress, new-onset diabetes, renal transplantation, C-REACTIVE PROTEIN, OXIDATIVE STRESS, LIPID-PEROXIDATION, BLOOD-PRESSURE, FATTY-ACIDS, MELLITUS, QUESTIONNAIRE, ANTIOXIDANTS, ASSOCIATION, MECHANISMS

View graph of relations

Download statistics

No data available

ID: 83560134