Plasma hemopexin activity in pregnancy and preeclampsiaBakker, W. W., Donker, R. B., Timmer, A., van Pampus, M. G., van Son, W. J., Aarnoudse, J. G., van Goor, H., Niezen-Koning, K. E., Navis, G., Borghuis, T., Jongman, R. M. & Faas, M. M., 2007, In : HYPERTENSION IN PREGNANCY. 26, 2, p. 227-239 13 p.
Research output: Contribution to journal › Article › Academic › peer-review
Objective: Plasma hemopexin activity, associated with increased vascular permeability, was evaluated in healthy pregnant and non-pregnant women and in pre-eclamptic women. Methods: Hemopexin activity and the hemopexin inhibitor, extracellular ATP, were assayed in plasma from pregnant (n=10), preeclamptic (n=9), and non-pregnant women (n=10) using standard methods. Abdominal fascia tissue fragments from preeclamptic and pregnant women were immunohistochemically stained for vascular ectoapyrase or ecto-5'nucleotidase. Results: The data show significantly enhanced Hx activity exclusively in plasma from pregnant women and significantly enhanced plasma ATP in pre-eclamptic women compared with the other groups. Dephosphorylation of preeclamptic plasma resulted in reactivation of Hx activity. Fascia tissue-samples from preeclamptic women showed reduced ecto-apyrase activity and enhanced ecto-5'nucleotidase activity compared to pregnant women. Conclusion: Enhanced hemopexin activity may be associated with normal pregnancy, but not with preeclampsia. Decreased hemopexin in pre-eclamptic patients may be due to enhanced plasma ATP, which is possibly promoted by diminished activity of vascular ecto-apyrase.
|Number of pages||13|
|Journal||HYPERTENSION IN PREGNANCY|
|Publication status||Published - 2007|
- hemopexin, pregnancy, preeclampsia, ADENINE-NUCLEOTIDES, HUMAN PLACENTA, ADENOSINE, CIRCULATION, MEMBRANES, INFUSION, PURINES, ATPASE