PKM2, STAT3 and HIF-1α: The Warburg's vicious circle

Demaria, M. & Poli, V., 1-Jul-2012, In : JAK-STAT. 1, 3, p. 194-6 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

The M2 isoform of pyruvate kinase, highly expressed in tumor cells, is known to engage a feed forward loop with the glycolysis master transcription factor HIF-1α. Gao and co-authors recently showed that dimeric PKM2 localizes to the nucleus in highly proliferating cancer cells, where it regulates in vivo growth by acting as a protein kinase and directly activating STAT3. STAT3 is therefore a novel player of the PKM2/HIF-1α feedback loop, since HIF-induced PKM2 activates STAT3 that in turn induces HIF-1α expression. These findings have profound implications for understanding the complex connections between gene regulation, metabolism, survival and proliferation in cancer.

Original languageEnglish
Pages (from-to)194-6
Number of pages3
Issue number3
Publication statusPublished - 1-Jul-2012
Externally publishedYes

ID: 26938087