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Physical inactivity: A risk factor and target for intervention in renal care

Zelle, D. M., Klaassen, G., van Adrichem, E., Bakker, S. J. L., Corpeleijn, E. & Navis, G., Mar-2017, In : Nature Reviews Nephrology. 13, 3, p. 152-168 17 p.

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  • Physical inactivity: a risk factor and target for intervention in renal care

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DOI

Regular physical activity is associated with an increased quality of life and reduced morbidity and mortality in the general population and in patients with chronic kidney disease (CKD). Physical activity, cardiorespiratory fitness, and muscle mass decrease even in the early stages of CKD, and continue to decrease with disease progression; notably, full recovery is generally not achieved with transplantation. The combined effects of uraemia and physical inactivity drive the loss of muscle mass. Regular physical activity benefits cardiometabolic, neuromuscular and cognitive function across all stages of CKD, and therefore provides an approach to address the multimorbidity of the CKD population. Interestingly, maintenance of muscle health is associated with renoprotective effects. Despite evidence of its benefits, physical activity and exercise management are not routinely addressed in the care of these patients. Although studies defining the optimum frequency, duration and intensity of physical activity are lacking, evidence from related fields can guide practical approaches to the care of patients with renal disease. Optimization of metabolic and nutritional status alongside promotion of physical activity is recommended. Behavioural approaches are now recognized as crucial in helping patients to adopt lifestyle changes and might prove valuable in integrating physical activity into renal care.

Original languageEnglish
Pages (from-to)152-168
Number of pages17
JournalNature Reviews Nephrology
Volume13
Issue number3
Publication statusPublished - Mar-2017

    Keywords

  • CHRONIC KIDNEY-DISEASE, RANDOMIZED CONTROLLED-TRIAL, QUALITY-OF-LIFE, CHRONIC-HEMODIALYSIS PATIENTS, FINNISH DIABETES PREVENTION, CORONARY-HEART-DISEASE, ALL-CAUSE MORTALITY, BODY-MASS INDEX, TRANSPLANT RECIPIENTS, SKELETAL-MUSCLE

ID: 39698760