Publication

Phylogenetic analysis of fungal ABC transporters

Kovalchuk, A. & Driessen, A. J. M., 16-Mar-2010, In : BMC Genomics. 11, 1, 21 p., 177.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Kovalchuk, A., & Driessen, A. J. M. (2010). Phylogenetic analysis of fungal ABC transporters. BMC Genomics, 11(1), [177]. https://doi.org/10.1186/1471-2164-11-177

Author

Kovalchuk, Andriy ; Driessen, Arnold J. M. / Phylogenetic analysis of fungal ABC transporters. In: BMC Genomics. 2010 ; Vol. 11, No. 1.

Harvard

Kovalchuk, A & Driessen, AJM 2010, 'Phylogenetic analysis of fungal ABC transporters', BMC Genomics, vol. 11, no. 1, 177. https://doi.org/10.1186/1471-2164-11-177

Standard

Phylogenetic analysis of fungal ABC transporters. / Kovalchuk, Andriy; Driessen, Arnold J. M.

In: BMC Genomics, Vol. 11, No. 1, 177, 16.03.2010.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Kovalchuk A, Driessen AJM. Phylogenetic analysis of fungal ABC transporters. BMC Genomics. 2010 Mar 16;11(1). 177. https://doi.org/10.1186/1471-2164-11-177


BibTeX

@article{7388112e558b497fb363a78104b07641,
title = "Phylogenetic analysis of fungal ABC transporters",
abstract = "Background: The superfamily of ABC proteins is among the largest known in nature. Its members are mainly, but not exclusively, involved in the transport of a broad range of substrates across biological membranes. Many contribute to multidrug resistance in microbial pathogens and cancer cells. The diversity of ABC proteins in fungi is comparable with those in multicellular animals, but so far fungal ABC proteins have barely been studied.Results: We performed a phylogenetic analysis of the ABC proteins extracted from the genomes of 27 fungal species from 18 orders representing 5 fungal phyla thereby covering the most important groups. Our analysis demonstrated that some of the subfamilies of ABC proteins remained highly conserved in fungi, while others have undergone a remarkable group-specific diversification. Members of the various fungal phyla also differed significantly in the number of ABC proteins found in their genomes, which is especially reduced in the yeast S. cerevisiae and S. pombe.Conclusions: Data obtained during our analysis should contribute to a better understanding of the diversity of the fungal ABC proteins and provide important clues about their possible biological functions.",
keywords = "BINDING CASSETTE PROTEIN, MULTIDRUG-RESISTANCE TRANSPORTER, MULTIPLE-DRUG RESISTANCE, NATURAL TOXIC COMPOUNDS, SACCHAROMYCES-CEREVISIAE, CANDIDA-ALBICANS, ASPERGILLUS-NIDULANS, FISSION YEAST, CRYPTOCOCCUS-NEOFORMANS, COMPLETE INVENTORY",
author = "Andriy Kovalchuk and Driessen, {Arnold J. M.}",
year = "2010",
month = mar,
day = "16",
doi = "10.1186/1471-2164-11-177",
language = "English",
volume = "11",
journal = "BMC Genomics",
issn = "1471-2164",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Phylogenetic analysis of fungal ABC transporters

AU - Kovalchuk, Andriy

AU - Driessen, Arnold J. M.

PY - 2010/3/16

Y1 - 2010/3/16

N2 - Background: The superfamily of ABC proteins is among the largest known in nature. Its members are mainly, but not exclusively, involved in the transport of a broad range of substrates across biological membranes. Many contribute to multidrug resistance in microbial pathogens and cancer cells. The diversity of ABC proteins in fungi is comparable with those in multicellular animals, but so far fungal ABC proteins have barely been studied.Results: We performed a phylogenetic analysis of the ABC proteins extracted from the genomes of 27 fungal species from 18 orders representing 5 fungal phyla thereby covering the most important groups. Our analysis demonstrated that some of the subfamilies of ABC proteins remained highly conserved in fungi, while others have undergone a remarkable group-specific diversification. Members of the various fungal phyla also differed significantly in the number of ABC proteins found in their genomes, which is especially reduced in the yeast S. cerevisiae and S. pombe.Conclusions: Data obtained during our analysis should contribute to a better understanding of the diversity of the fungal ABC proteins and provide important clues about their possible biological functions.

AB - Background: The superfamily of ABC proteins is among the largest known in nature. Its members are mainly, but not exclusively, involved in the transport of a broad range of substrates across biological membranes. Many contribute to multidrug resistance in microbial pathogens and cancer cells. The diversity of ABC proteins in fungi is comparable with those in multicellular animals, but so far fungal ABC proteins have barely been studied.Results: We performed a phylogenetic analysis of the ABC proteins extracted from the genomes of 27 fungal species from 18 orders representing 5 fungal phyla thereby covering the most important groups. Our analysis demonstrated that some of the subfamilies of ABC proteins remained highly conserved in fungi, while others have undergone a remarkable group-specific diversification. Members of the various fungal phyla also differed significantly in the number of ABC proteins found in their genomes, which is especially reduced in the yeast S. cerevisiae and S. pombe.Conclusions: Data obtained during our analysis should contribute to a better understanding of the diversity of the fungal ABC proteins and provide important clues about their possible biological functions.

KW - BINDING CASSETTE PROTEIN

KW - MULTIDRUG-RESISTANCE TRANSPORTER

KW - MULTIPLE-DRUG RESISTANCE

KW - NATURAL TOXIC COMPOUNDS

KW - SACCHAROMYCES-CEREVISIAE

KW - CANDIDA-ALBICANS

KW - ASPERGILLUS-NIDULANS

KW - FISSION YEAST

KW - CRYPTOCOCCUS-NEOFORMANS

KW - COMPLETE INVENTORY

U2 - 10.1186/1471-2164-11-177

DO - 10.1186/1471-2164-11-177

M3 - Article

VL - 11

JO - BMC Genomics

JF - BMC Genomics

SN - 1471-2164

IS - 1

M1 - 177

ER -

ID: 5060138