Publication

Phospholipid transfer protein activity and incident type 2 diabetes mellitus

Abbasi, A., Dallinga-Thie, G. M. & Dullaart, R. P. F., 15-Jan-2015, In : Clinica chimica acta. 439, p. 38-41 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Abbasi, A., Dallinga-Thie, G. M., & Dullaart, R. P. F. (2015). Phospholipid transfer protein activity and incident type 2 diabetes mellitus. Clinica chimica acta, 439, 38-41. https://doi.org/10.1016/j.cca.2014.09.035

Author

Abbasi, Ali ; Dallinga-Thie, Geesje M. ; Dullaart, Robin P. F. / Phospholipid transfer protein activity and incident type 2 diabetes mellitus. In: Clinica chimica acta. 2015 ; Vol. 439. pp. 38-41.

Harvard

Abbasi, A, Dallinga-Thie, GM & Dullaart, RPF 2015, 'Phospholipid transfer protein activity and incident type 2 diabetes mellitus', Clinica chimica acta, vol. 439, pp. 38-41. https://doi.org/10.1016/j.cca.2014.09.035

Standard

Phospholipid transfer protein activity and incident type 2 diabetes mellitus. / Abbasi, Ali; Dallinga-Thie, Geesje M.; Dullaart, Robin P. F.

In: Clinica chimica acta, Vol. 439, 15.01.2015, p. 38-41.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Abbasi A, Dallinga-Thie GM, Dullaart RPF. Phospholipid transfer protein activity and incident type 2 diabetes mellitus. Clinica chimica acta. 2015 Jan 15;439:38-41. https://doi.org/10.1016/j.cca.2014.09.035


BibTeX

@article{eb422ff7cd5e4c28a4a26b0fac91c729,
title = "Phospholipid transfer protein activity and incident type 2 diabetes mellitus",
abstract = "Background: The plasma activity of phospholipid transfer protein (PLTP), which has multifaceted functions in lipoprotein metabolism and in inflammatory responses, is elevated in insulin resistant conditions. We determined the association of plasma PLTP activity with incident type 2 diabetes mellitus (T2DM).Methods: Plasma PLTP activity was determined using a liposome vesicle-HDL system in 218 men without T2DM at baseline. We used logistic regression models to establish odds ratios (ORs) for incident T2DM.Results: Twenty four men developed T2DM over 9.4-year follow-up. Plasma PLTP activity was higher in incident T2DM cases (p = 0.009). We observed 82{\%} higher odds for T2DM per 1-SD increase in PLTP activity. Multivariable modeling showed that the association of PLTP activity with T2DM was independent of clinical risk factors including age, and either the metabolic syndrome, individual metabolic syndrome components, total cholesterol, HOMA-IR or albuminuria (ORs ranging from 1.64 (95{\%} CI 1.03-2.66) to 1.87 (1.19-3.010)).Conclusions: Elevated plasma PLTP activity may predict an increased risk of 12DM in men. (C) 2014 Elsevier B.V. All rights reserved.",
keywords = "Epidemiology, Phospholipid transfer protein activity, Risk factor, Type 2 diabetes mellitus, GLUCOSE, MARKER",
author = "Ali Abbasi and Dallinga-Thie, {Geesje M.} and Dullaart, {Robin P. F.}",
year = "2015",
month = "1",
day = "15",
doi = "10.1016/j.cca.2014.09.035",
language = "English",
volume = "439",
pages = "38--41",
journal = "Clinica chimica acta",
issn = "0009-8981",
publisher = "ELSEVIER SCIENCE BV",

}

RIS

TY - JOUR

T1 - Phospholipid transfer protein activity and incident type 2 diabetes mellitus

AU - Abbasi, Ali

AU - Dallinga-Thie, Geesje M.

AU - Dullaart, Robin P. F.

PY - 2015/1/15

Y1 - 2015/1/15

N2 - Background: The plasma activity of phospholipid transfer protein (PLTP), which has multifaceted functions in lipoprotein metabolism and in inflammatory responses, is elevated in insulin resistant conditions. We determined the association of plasma PLTP activity with incident type 2 diabetes mellitus (T2DM).Methods: Plasma PLTP activity was determined using a liposome vesicle-HDL system in 218 men without T2DM at baseline. We used logistic regression models to establish odds ratios (ORs) for incident T2DM.Results: Twenty four men developed T2DM over 9.4-year follow-up. Plasma PLTP activity was higher in incident T2DM cases (p = 0.009). We observed 82% higher odds for T2DM per 1-SD increase in PLTP activity. Multivariable modeling showed that the association of PLTP activity with T2DM was independent of clinical risk factors including age, and either the metabolic syndrome, individual metabolic syndrome components, total cholesterol, HOMA-IR or albuminuria (ORs ranging from 1.64 (95% CI 1.03-2.66) to 1.87 (1.19-3.010)).Conclusions: Elevated plasma PLTP activity may predict an increased risk of 12DM in men. (C) 2014 Elsevier B.V. All rights reserved.

AB - Background: The plasma activity of phospholipid transfer protein (PLTP), which has multifaceted functions in lipoprotein metabolism and in inflammatory responses, is elevated in insulin resistant conditions. We determined the association of plasma PLTP activity with incident type 2 diabetes mellitus (T2DM).Methods: Plasma PLTP activity was determined using a liposome vesicle-HDL system in 218 men without T2DM at baseline. We used logistic regression models to establish odds ratios (ORs) for incident T2DM.Results: Twenty four men developed T2DM over 9.4-year follow-up. Plasma PLTP activity was higher in incident T2DM cases (p = 0.009). We observed 82% higher odds for T2DM per 1-SD increase in PLTP activity. Multivariable modeling showed that the association of PLTP activity with T2DM was independent of clinical risk factors including age, and either the metabolic syndrome, individual metabolic syndrome components, total cholesterol, HOMA-IR or albuminuria (ORs ranging from 1.64 (95% CI 1.03-2.66) to 1.87 (1.19-3.010)).Conclusions: Elevated plasma PLTP activity may predict an increased risk of 12DM in men. (C) 2014 Elsevier B.V. All rights reserved.

KW - Epidemiology

KW - Phospholipid transfer protein activity

KW - Risk factor

KW - Type 2 diabetes mellitus

KW - GLUCOSE

KW - MARKER

U2 - 10.1016/j.cca.2014.09.035

DO - 10.1016/j.cca.2014.09.035

M3 - Article

VL - 439

SP - 38

EP - 41

JO - Clinica chimica acta

JF - Clinica chimica acta

SN - 0009-8981

ER -

ID: 17406689