Pharmacology and structures of the free base of the anaesthetic kazcaine and its complex with beta-cyclodextrinKemelbekov, U. S., Hagenbach, A., Lentz, D., Imachova, S. O., Pichkhadze, G. M., Rustembekov, Z. I., Beketov, K. M., Praliev, K. D., Gabdulkhakov, A., Guskov, A. & Saenger, W., Dec-2010, In : Journal of inclusion phenomena and macrocyclic chemistry. 68, 3-4, p. 323-330 8 p.
Research output: Contribution to journal › Article › Academic › peer-review
The base form of the local anaesthetic kazcaine (BFK, [1-(2-ethoxyethyl)-4-ethynyl-4-benzoyloxypiperidine, C(18)H(23)NO(3)]) and beta-cyclodextrin (beta-CD) co-crystallized as BFK:beta-CD inclusion complex in 1:2 M ratio from a mixture of water and ethanol while the filtered mother liquor yielded crystals of free BFK. X-ray diffraction showed that the crystals of BFK and its inclusion complex with beta-CD belong to monoclinic (P2(1)/c) and triclinic (P1) space groups, respectively. The crystals of free BFK are stabilized by pairs of C-Ha
|Number of pages||8|
|Journal||Journal of inclusion phenomena and macrocyclic chemistry|
|Publication status||Published - Dec-2010|
- Kazcaine base, Cyclodextrin, Crystal structure, X-ray diffraction, Pharmacological properties, Anaesthetic