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Pharmacology and structures of the free base of the anaesthetic kazcaine and its complex with beta-cyclodextrin

Kemelbekov, U. S., Hagenbach, A., Lentz, D., Imachova, S. O., Pichkhadze, G. M., Rustembekov, Z. I., Beketov, K. M., Praliev, K. D., Gabdulkhakov, A., Guskov, A. & Saenger, W., Dec-2010, In : Journal of inclusion phenomena and macrocyclic chemistry. 68, 3-4, p. 323-330 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • U. S. Kemelbekov
  • A. Hagenbach
  • D. Lentz
  • Sh. O. Imachova
  • G. M. Pichkhadze
  • Zh. I. Rustembekov
  • K. M. Beketov
  • K. D. Praliev
  • A. Gabdulkhakov
  • A. Guskov
  • W. Saenger

The base form of the local anaesthetic kazcaine (BFK, [1-(2-ethoxyethyl)-4-ethynyl-4-benzoyloxypiperidine, C(18)H(23)NO(3)]) and beta-cyclodextrin (beta-CD) co-crystallized as BFK:beta-CD inclusion complex in 1:2 M ratio from a mixture of water and ethanol while the filtered mother liquor yielded crystals of free BFK. X-ray diffraction showed that the crystals of BFK and its inclusion complex with beta-CD belong to monoclinic (P2(1)/c) and triclinic (P1) space groups, respectively. The crystals of free BFK are stabilized by pairs of C-Ha

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalJournal of inclusion phenomena and macrocyclic chemistry
Volume68
Issue number3-4
Publication statusPublished - Dec-2010
Externally publishedYes

    Keywords

  • Kazcaine base, Cyclodextrin, Crystal structure, X-ray diffraction, Pharmacological properties, Anaesthetic

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