Publication

Pharmacological treatment of hyperinsulineamia in rats depends on coping style

Boersma, G., Benthem, L., van Dijk, G., Steimer, T. J. & Scheurink, A. J. W., 1-Mar-2011, In : European Journal of Pharmacology. 654, 1, p. 122-127 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Boersma, G., Benthem, L., van Dijk, G., Steimer, T. J., & Scheurink, A. J. W. (2011). Pharmacological treatment of hyperinsulineamia in rats depends on coping style. European Journal of Pharmacology, 654(1), 122-127. https://doi.org/10.1016/j.ejphar.2010.12.017

Author

Boersma, Gretha ; Benthem, Lambertus ; van Dijk, Gertjan ; Steimer, Thierry J. ; Scheurink, Anton J. W. / Pharmacological treatment of hyperinsulineamia in rats depends on coping style. In: European Journal of Pharmacology. 2011 ; Vol. 654, No. 1. pp. 122-127.

Harvard

Boersma, G, Benthem, L, van Dijk, G, Steimer, TJ & Scheurink, AJW 2011, 'Pharmacological treatment of hyperinsulineamia in rats depends on coping style', European Journal of Pharmacology, vol. 654, no. 1, pp. 122-127. https://doi.org/10.1016/j.ejphar.2010.12.017

Standard

Pharmacological treatment of hyperinsulineamia in rats depends on coping style. / Boersma, Gretha; Benthem, Lambertus; van Dijk, Gertjan; Steimer, Thierry J.; Scheurink, Anton J. W.

In: European Journal of Pharmacology, Vol. 654, No. 1, 01.03.2011, p. 122-127.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Boersma G, Benthem L, van Dijk G, Steimer TJ, Scheurink AJW. Pharmacological treatment of hyperinsulineamia in rats depends on coping style. European Journal of Pharmacology. 2011 Mar 1;654(1):122-127. https://doi.org/10.1016/j.ejphar.2010.12.017


BibTeX

@article{ce33afd2509a47599108e5a4052cf8fa,
title = "Pharmacological treatment of hyperinsulineamia in rats depends on coping style",
abstract = "Passive and proactive coping styles are associated with marked differences in behavioral and neuroendocrine responses. Previous studies revealed that the passive individuals are more prone to hyperinsulineamia. Likewise, we hypothesize that different coping styles may require different drugs to treat this. We tested this by treating passive and proactive rats (Roman Low Avoidance and Roman High Avoidance rats respectively) with either Rosiglitazone or with RU486. After eight days of treatment we performed and intravenous glucose tolerance test (IVGTT) and we compared the insulin and glucose levels with those measured during the IVGTT at baseline. Rosiglitazone improved insulin levels during an IVGTT in both passive and proactive coping styles. RU486, however, lowered insulin levels only in rats with a passive coping style. This study suggests that insight in the neuroendocrine differences between passive and proactive coping styles may provide an extra impulse to improve treatment of insulin resistance, since it allows the application of drugs targeted at the individual. (C) 2010 Elsevier B.V. All rights reserved.",
keywords = "Rosiglitazone, RU486, Glucocorticoid, PPAR gamma agonist, Intravenous glucose tolerance test, ROMAN HIGH-AVOIDANCE, INSULIN-RESISTANCE, METABOLIC SYNDROME, FAT, GLUCOSE, STRESS, PATTERNS, INFUSION, MUSCLE, RU-486",
author = "Gretha Boersma and Lambertus Benthem and {van Dijk}, Gertjan and Steimer, {Thierry J.} and Scheurink, {Anton J. W.}",
year = "2011",
month = "3",
day = "1",
doi = "10.1016/j.ejphar.2010.12.017",
language = "English",
volume = "654",
pages = "122--127",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "ELSEVIER SCIENCE BV",
number = "1",

}

RIS

TY - JOUR

T1 - Pharmacological treatment of hyperinsulineamia in rats depends on coping style

AU - Boersma, Gretha

AU - Benthem, Lambertus

AU - van Dijk, Gertjan

AU - Steimer, Thierry J.

AU - Scheurink, Anton J. W.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Passive and proactive coping styles are associated with marked differences in behavioral and neuroendocrine responses. Previous studies revealed that the passive individuals are more prone to hyperinsulineamia. Likewise, we hypothesize that different coping styles may require different drugs to treat this. We tested this by treating passive and proactive rats (Roman Low Avoidance and Roman High Avoidance rats respectively) with either Rosiglitazone or with RU486. After eight days of treatment we performed and intravenous glucose tolerance test (IVGTT) and we compared the insulin and glucose levels with those measured during the IVGTT at baseline. Rosiglitazone improved insulin levels during an IVGTT in both passive and proactive coping styles. RU486, however, lowered insulin levels only in rats with a passive coping style. This study suggests that insight in the neuroendocrine differences between passive and proactive coping styles may provide an extra impulse to improve treatment of insulin resistance, since it allows the application of drugs targeted at the individual. (C) 2010 Elsevier B.V. All rights reserved.

AB - Passive and proactive coping styles are associated with marked differences in behavioral and neuroendocrine responses. Previous studies revealed that the passive individuals are more prone to hyperinsulineamia. Likewise, we hypothesize that different coping styles may require different drugs to treat this. We tested this by treating passive and proactive rats (Roman Low Avoidance and Roman High Avoidance rats respectively) with either Rosiglitazone or with RU486. After eight days of treatment we performed and intravenous glucose tolerance test (IVGTT) and we compared the insulin and glucose levels with those measured during the IVGTT at baseline. Rosiglitazone improved insulin levels during an IVGTT in both passive and proactive coping styles. RU486, however, lowered insulin levels only in rats with a passive coping style. This study suggests that insight in the neuroendocrine differences between passive and proactive coping styles may provide an extra impulse to improve treatment of insulin resistance, since it allows the application of drugs targeted at the individual. (C) 2010 Elsevier B.V. All rights reserved.

KW - Rosiglitazone

KW - RU486

KW - Glucocorticoid

KW - PPAR gamma agonist

KW - Intravenous glucose tolerance test

KW - ROMAN HIGH-AVOIDANCE

KW - INSULIN-RESISTANCE

KW - METABOLIC SYNDROME

KW - FAT

KW - GLUCOSE

KW - STRESS

KW - PATTERNS

KW - INFUSION

KW - MUSCLE

KW - RU-486

U2 - 10.1016/j.ejphar.2010.12.017

DO - 10.1016/j.ejphar.2010.12.017

M3 - Article

VL - 654

SP - 122

EP - 127

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1

ER -

ID: 5268676