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Pharmacological treatment of hyperinsulineamia in rats depends on coping style

Boersma, G., Benthem, L., van Dijk, G., Steimer, T. J. & Scheurink, A. J. W., 1-Mar-2011, In : European Journal of Pharmacology. 654, 1, p. 122-127 6 p.

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DOI

Passive and proactive coping styles are associated with marked differences in behavioral and neuroendocrine responses. Previous studies revealed that the passive individuals are more prone to hyperinsulineamia. Likewise, we hypothesize that different coping styles may require different drugs to treat this. We tested this by treating passive and proactive rats (Roman Low Avoidance and Roman High Avoidance rats respectively) with either Rosiglitazone or with RU486. After eight days of treatment we performed and intravenous glucose tolerance test (IVGTT) and we compared the insulin and glucose levels with those measured during the IVGTT at baseline. Rosiglitazone improved insulin levels during an IVGTT in both passive and proactive coping styles. RU486, however, lowered insulin levels only in rats with a passive coping style. This study suggests that insight in the neuroendocrine differences between passive and proactive coping styles may provide an extra impulse to improve treatment of insulin resistance, since it allows the application of drugs targeted at the individual. (C) 2010 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)122-127
Number of pages6
JournalEuropean Journal of Pharmacology
Volume654
Issue number1
Publication statusPublished - 1-Mar-2011

    Keywords

  • Rosiglitazone, RU486, Glucocorticoid, PPAR gamma agonist, Intravenous glucose tolerance test, ROMAN HIGH-AVOIDANCE, INSULIN-RESISTANCE, METABOLIC SYNDROME, FAT, GLUCOSE, STRESS, PATTERNS, INFUSION, MUSCLE, RU-486

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