Publication

Pharmacokinetic/pharmacodynamic modeling of rocuronium in myasthenic patients is improved by taking into account the number of unbound acetylcholine receptors

De Haes, A., Proost, JH., Kuks, JBM., van den Tol, DC. & Wierda, JMKH., Sep-2002, In : Anesthesia and Analgesia. 95, 3, p. 588-596 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

De Haes, A., Proost, JH., Kuks, JBM., van den Tol, DC., & Wierda, JMKH. (2002). Pharmacokinetic/pharmacodynamic modeling of rocuronium in myasthenic patients is improved by taking into account the number of unbound acetylcholine receptors. Anesthesia and Analgesia, 95(3), 588-596. https://doi.org/10.1213/01.ANE.0000023282.00799.CD

Author

De Haes, A ; Proost, JH ; Kuks, JBM ; van den Tol, DC ; Wierda, JMKH. / Pharmacokinetic/pharmacodynamic modeling of rocuronium in myasthenic patients is improved by taking into account the number of unbound acetylcholine receptors. In: Anesthesia and Analgesia. 2002 ; Vol. 95, No. 3. pp. 588-596.

Harvard

De Haes, A, Proost, JH, Kuks, JBM, van den Tol, DC & Wierda, JMKH 2002, 'Pharmacokinetic/pharmacodynamic modeling of rocuronium in myasthenic patients is improved by taking into account the number of unbound acetylcholine receptors' Anesthesia and Analgesia, vol. 95, no. 3, pp. 588-596. https://doi.org/10.1213/01.ANE.0000023282.00799.CD

Standard

Pharmacokinetic/pharmacodynamic modeling of rocuronium in myasthenic patients is improved by taking into account the number of unbound acetylcholine receptors. / De Haes, A; Proost, JH; Kuks, JBM; van den Tol, DC; Wierda, JMKH.

In: Anesthesia and Analgesia, Vol. 95, No. 3, 09.2002, p. 588-596.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

De Haes A, Proost JH, Kuks JBM, van den Tol DC, Wierda JMKH. Pharmacokinetic/pharmacodynamic modeling of rocuronium in myasthenic patients is improved by taking into account the number of unbound acetylcholine receptors. Anesthesia and Analgesia. 2002 Sep;95(3):588-596. https://doi.org/10.1213/01.ANE.0000023282.00799.CD


BibTeX

@article{6e8b796ebfc5443391ff0bab8b9214e8,
title = "Pharmacokinetic/pharmacodynamic modeling of rocuronium in myasthenic patients is improved by taking into account the number of unbound acetylcholine receptors",
abstract = "Patients with myasthenia gravis are more sensitive than healthy patients to nondepolarizing neuromuscular blocking drugs. We performed a pharmacokinetic/pharmacodynamic modeling study of rocuronium in eight myasthenic patients and eight matched control patients. Patients were anesthetized with propofol and sufentanil and a mixture of nitrous oxide/oxygen. Mechanomyographical monitoring of the adductor pollicis was applied. Rocuronium was infused at a rate of 25 mug . kg(-1) . min(-1) in myasthenic patients and 116.7 mug . kg(-1) . min(-1) in control patients and was terminated at 70{\%} neuromuscular block. Arterial blood samples were drawn during onset and offset of the block and for 4 h after the administration of rocuronium. Plasma concentrations were determined by high-performance liquid chromatography. Pharmacokinetic/pharmacodynamic modeling was performed by using the Sheiner model and the unbound receptor model (URM), which takes into account the number of unbound acetylcholine receptors. The effective concentration at 50{\%} effect and the steepness of the concentration-effect relationship were significantly decreased in myasthenic patients. Both the URM and the Sheiner model provided an adequate fit in myasthenic patients. The acetylcholine receptor concentration was significantly decreased in myasthenic patients. The URM explains the observed differences in time course and potency, whereas the Sheiner model does not.",
keywords = "GRAVIS, VECURONIUM, ATRACURIUM, PHARMACOKINETICS, PHARMACODYNAMICS, MIVACURIUM, POTENCY, DRUGS, TIME",
author = "{De Haes}, A and JH Proost and JBM Kuks and {van den Tol}, DC and JMKH Wierda",
year = "2002",
month = "9",
doi = "10.1213/01.ANE.0000023282.00799.CD",
language = "English",
volume = "95",
pages = "588--596",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "3",

}

RIS

TY - JOUR

T1 - Pharmacokinetic/pharmacodynamic modeling of rocuronium in myasthenic patients is improved by taking into account the number of unbound acetylcholine receptors

AU - De Haes, A

AU - Proost, JH

AU - Kuks, JBM

AU - van den Tol, DC

AU - Wierda, JMKH

PY - 2002/9

Y1 - 2002/9

N2 - Patients with myasthenia gravis are more sensitive than healthy patients to nondepolarizing neuromuscular blocking drugs. We performed a pharmacokinetic/pharmacodynamic modeling study of rocuronium in eight myasthenic patients and eight matched control patients. Patients were anesthetized with propofol and sufentanil and a mixture of nitrous oxide/oxygen. Mechanomyographical monitoring of the adductor pollicis was applied. Rocuronium was infused at a rate of 25 mug . kg(-1) . min(-1) in myasthenic patients and 116.7 mug . kg(-1) . min(-1) in control patients and was terminated at 70% neuromuscular block. Arterial blood samples were drawn during onset and offset of the block and for 4 h after the administration of rocuronium. Plasma concentrations were determined by high-performance liquid chromatography. Pharmacokinetic/pharmacodynamic modeling was performed by using the Sheiner model and the unbound receptor model (URM), which takes into account the number of unbound acetylcholine receptors. The effective concentration at 50% effect and the steepness of the concentration-effect relationship were significantly decreased in myasthenic patients. Both the URM and the Sheiner model provided an adequate fit in myasthenic patients. The acetylcholine receptor concentration was significantly decreased in myasthenic patients. The URM explains the observed differences in time course and potency, whereas the Sheiner model does not.

AB - Patients with myasthenia gravis are more sensitive than healthy patients to nondepolarizing neuromuscular blocking drugs. We performed a pharmacokinetic/pharmacodynamic modeling study of rocuronium in eight myasthenic patients and eight matched control patients. Patients were anesthetized with propofol and sufentanil and a mixture of nitrous oxide/oxygen. Mechanomyographical monitoring of the adductor pollicis was applied. Rocuronium was infused at a rate of 25 mug . kg(-1) . min(-1) in myasthenic patients and 116.7 mug . kg(-1) . min(-1) in control patients and was terminated at 70% neuromuscular block. Arterial blood samples were drawn during onset and offset of the block and for 4 h after the administration of rocuronium. Plasma concentrations were determined by high-performance liquid chromatography. Pharmacokinetic/pharmacodynamic modeling was performed by using the Sheiner model and the unbound receptor model (URM), which takes into account the number of unbound acetylcholine receptors. The effective concentration at 50% effect and the steepness of the concentration-effect relationship were significantly decreased in myasthenic patients. Both the URM and the Sheiner model provided an adequate fit in myasthenic patients. The acetylcholine receptor concentration was significantly decreased in myasthenic patients. The URM explains the observed differences in time course and potency, whereas the Sheiner model does not.

KW - GRAVIS

KW - VECURONIUM

KW - ATRACURIUM

KW - PHARMACOKINETICS

KW - PHARMACODYNAMICS

KW - MIVACURIUM

KW - POTENCY

KW - DRUGS

KW - TIME

U2 - 10.1213/01.ANE.0000023282.00799.CD

DO - 10.1213/01.ANE.0000023282.00799.CD

M3 - Article

VL - 95

SP - 588

EP - 596

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 3

ER -

ID: 4038833