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Pharmacoeconomic evaluations of pharmacogenetic and genomic screening programmes: A systematic review on content and adherence to guidelines

Vegter, S., Boersma, C., Rozenbaum, M., Wilffert, B., Navis, G. & Postma, M. J., Jul-2008, In : Pharmacoeconomics. 26, 7, p. 569-587 19 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The fields of pharmacogenetics and pharmacogenomics have become important practical tools to progress goals in medical and pharmaceutical research and development. As more screening tests are being developed, with some already used in clinical practice, consideration of cost-effectiveness implications is important. A systematic review was performed on the content of and adherence to pharmacoeconomic guidelines of recent pharmacoeconomic analyses performed in the field of pharmacogenetics and pharmacogenomics. Economic analyses of screening strategies for genetic variations, which were evidence-based and assumed to be associated with drug efficacy or safety, were included in the review. The 20 papers included cover a variety of healthcare issues, including screening tests on several cytochrome P450 (CYP) enzyme genes, thiopurine S-methyltransferase (TMPT) and angiotensin-converting enzyme (ACE) insertion deletion (ACE I/D) polymorphisms. Most economic analyses reported that genetic screening was cost effective and often even clearly dominated existing non-screening strategies. However, we found a lack of standardization regarding aspects such as the perspective of the analysis, factors included in the sensitivity analysis and the applied discount rates. In particular, an important limitation of several studies related to the failure to provide a sufficient evidence-based rationale for an association between genotype and phenotype. Future economic analyses should be conducted utilizing correct methods, with adherence to guidelines and including extensive sensitivity analyses. Most importantly, genetic screening strategies should be based on good evidence-based rationales. For these goals, we provide a list of recommendations for good pharmacoeconomic practice deemed useful in the fields of pharmacogenetics and pharmacogenomics, regardless of country and origin of the economic analysis. © 2008 Adis Data Information BV. All rights reserved.
Original languageEnglish
Pages (from-to)569-587
Number of pages19
JournalPharmacoeconomics
Volume26
Issue number7
Publication statusPublished - Jul-2008

    Keywords

  • Cost effectiveness, Genetic Screening, Pharmacogenomics, 5,10 methylenetetrahydrofolate reductase (FADH2), abacavir, acenocoumarol, alpha adducin, aminoglycoside, clozapine, cytochrome P450 2C19, cytochrome P450 2C9, cytochrome P450 2D6, dihydropyrimidine dehydrogenase, dipeptidyl carboxypeptidase, drug metabolizing enzyme, gefitinib, HLA antigen, hydroxymethylglutaryl coenzyme A reductase inhibitor, phenprocoumon, reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone), RNA 12S, tamoxifen, thiopurine methyltransferase, warfarin, clinical practice, cost control, cost effectiveness analysis, drug efficacy, drug hypersensitivity, drug safety, economic aspect, evidence based practice, gene deletion, gene insertion, genetic polymorphism, genetic screening, genetic variability, genotype, Gram negative infection, health care, hearing impairment, high risk patient, highly active antiretroviral therapy, human, Human immunodeficiency virus infection, hypercholesterolemia, hypotension, non insulin dependent diabetes mellitus, pharmacodynamics, pharmacogenetics, pharmacogenomics, phenotype, practice guideline, prevalence, priority journal, review, schizophrenia, sensitivity and specificity, standardization, systematic review

ID: 2026501