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PET-based analysis of tumor glucose metabolism and tumor hypoxia before and during anti-neoplastic treatment

Bollineni, V., 2015, [S.l.]: [S.n.]. 155 p.

Research output: ThesisThesis fully internal (DIV)Academic

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  • Vikram Bollineni
Tumor hypoxia is an important contributor to chemo-radiotherapy resistance. This has been demonstrated in several tumor types including non-small cell lung cancer and head and neck squamous cell carcinoma. Tumor hypoxia is a dynamic process, some parts of the tumor exhibit higher levels of hypoxia than others due to differences in blood flow as a result of constantly changing tumor microenvironment. Therefore, precise delivery of higher radiation doses per fraction to the specific hypoxic sub-volumes of tumor identified by FAZA-PET imaging may improve the therapeutic ratio by increasing local tumor control without inducing excess radiation induced side effects. Therefore, it is necessary to identify spatio-temporal dynamics of tumor hypoxia during treatment. In our study, FAZA-PET imaging is able to detect heterogeneous distribution of hypoxic sub-volumes out of homogeneous FDG background in a tumor. Most importantly we observed relatively stable tumor hypoxia at FAZA-week 2 of chemoradiotherapy. Hence, FAZA-PET might be developed into a tool for guiding adaptive radiotherapy treatment planning. However, additional studies are needed on the spatial-temporal dynamics of tumor hypoxia, to stratify patients who may benefit from hypoxia based radiotherapy treatment planning before implementation.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
Award date14-Jan-2015
Place of Publication[S.l.]
Publisher
Print ISBNs978-90-367-7583-0
Electronic ISBNs978-90-367-7582-3
Publication statusPublished - 2015

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