Publication

PET Imaging with S-[C-11]Methyl-L-Cysteine and L-[Methyl-C-11]Methionine in Rat Models of Glioma, Glioma Radiotherapy, and Neuroinflammation

Parente, A., van Waarde, A., Shoji, A., de Paula Faria, D., Maas, B., Zijlma, R., Dierckx, R., Langendijk, J. A., de Vries, E. & Doorduin, J., Jun-2018, In : Molecular Imaging and Biology. 20, 3, p. 465-472 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

PURPOSE: S-[(11)C]-methyl-L-cysteine ([(11)C]MCYS) has been claimed to offer higher tumor selectivity than L-[methyl- (11)C]methionine ([(11)C]MET). We examined this claim in animal models.

PROCEDURES: Rats with implanted untreated (n = 10) or irradiated (n = 7, 1 × 25 Gy, on day 8) orthotopic gliomas were scanned after 6, 9, and 12 days, using positron emission tomography. Rats with striatal injections of saline (n = 9) or bacterial lipopolysaccharide (n = 9) were scanned after 3 days.

RESULTS: Uptake of the two tracers in untreated gliomas was similar. [(11)C]MCYS was not accumulated in salivary glands, nasal epithelium, and healing wounds, in contrast to [(11)C]MET, but showed 40 % higher accumulation in the healthy brain. Both tracers showed a reduced tumor uptake 4 days after irradiation and minor accumulation in inflamed striatum. [(11)C]MCYS indicated higher lesion volumes than [(11)C]MET (untreated tumor + 47 %; irradiated tumor up to + 500 %; LPS-inflamed striatum + 240 %).

CONCLUSIONS: [(11)C]MCYS was less accumulated in some non-tumor tissues than [(11)C]MET, but showed lower tumor-to-brain contrast.

Original languageEnglish
Pages (from-to)465-472
Number of pages8
JournalMolecular Imaging and Biology
Volume20
Issue number3
Early online date30-Oct-2017
Publication statusPublished - Jun-2018

    Keywords

  • Amino acids, Brain tumors, Inflammation, Brain, Positron emission tomography, Small animal imaging, INFLAMMATION, TUMOR

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