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Perioperative goal-directed therapy - What is the evidence?

Kaufmann, T., Saugel, B. & Scheeren, T. W. L., Jun-2019, In : Best practice & research. Clinical anaesthesiology. 33, 2, p. 179-187 9 p.

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  • Perioperative goal-directed therapy – What is the evidence

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DOI

Perioperative goal-directed therapy aims at optimizing global hemodynamics during the perioperative period by titrating fluids, vasopressors, and/or inotropes to predefined hemodynamic goals. There is evidence on the benefit of perioperative goal-directed therapy, but its adoption into clinical practice is slow and incomprehensive. Current evidence indicates that treating patients according to perioperative goal-directed therapy protocols reduces morbidity and mortality, particularly in patients having high-risk surgery. Perioperative goal-directed therapy protocols need to be started early, should include vasoactive agents in addition to fluids, and should target blood flow related variables. Future promising developments in the field of perioperative goal-directed therapy include personalized hemodynamic management and closed-loop system management. (C) 2019 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)179-187
Number of pages9
JournalBest practice & research. Clinical anaesthesiology
Volume33
Issue number2
Publication statusPublished - Jun-2019

    Keywords

  • hemodynamic monitoring, cardiovascular dynamics, cardiac output, pulse pressure variation, stroke volume variation, MECHANICALLY VENTILATED PATIENTS, RANDOMIZED CONTROLLED-TRIAL, OXYGEN DELIVERY, CARDIAC-OUTPUT, ARTERIAL-PRESSURE, FLUID MANAGEMENT, STROKE VOLUME, PREOPERATIVE OPTIMIZATION, HEMODYNAMIC OPTIMIZATION, SUPRANORMAL VALUES

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