Periodontitis is characterized by elevated PAI-1 activityBizzarro, S., van der Velden, U., ten Heggeler, J. M. A. G., Leivadaros, E., Hoek, F. J., Gerdes, V. E. A., Bakker, S. J. L., Gans, R. O. B., ten Cate, H. & Loos, B. G., Jul-2007, In : Journal of Clinical Periodontology. 34, 7, p. 574-580 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
Objectives: Periodontitis is a chronic infectious disease and has been associated with cardiovascular diseases (CVD). We investigated whether plasma levels of markers of a prothrombotic state were elevated in patients with periodontitis in comparison with healthy controls.
Materials and methods: Untreated patients with moderate (n=53) and severe periodontitis (n=38) and healthy controls (n=39) were recruited. Levels of von Willebrand factor (vWF), prothrombin fragment 1+2 (F1+2), plasminogen activator inhibitor-1 (PAI-1) activity and D-dimer were measured as markers of a prothrombotic state.
Results: The erythrocyte sedimentation rate (ESR), plasma C-reactive protein (CRP) and leucocyte counts (WBC) were significantly higher in patients with periodontitis. No statistically significant difference was found among the three groups for vWF (p=0.264), F1+2 (p=0.295) and D-dimer (p=0.572). However, PAI-1 was clearly elevated in the severe periodontitis group (p=0.001), even after adjusting for potential confounding factors (p(adj)=0.004). Moreover, more patients than controls were having vWF and PAI-1 levels above the respective population medians.
Conclusions: In periodontitis, elevated levels of PAI-1 activity are observed compared with healthy controls. This may increase the potential for impaired fibrinolysis, a condition that results in a prothrombotic state. We suggest that this state, if left untreated, may contribute to an increased risk for CVD.
|Number of pages||7|
|Journal||Journal of Clinical Periodontology|
|Publication status||Published - Jul-2007|
- D-dimer, F1+2, PAI-1, periodontitis, vWF, CORONARY-HEART-DISEASE, C-REACTIVE PROTEIN, PLASMINOGEN-ACTIVATOR INHIBITOR-1, FIBRIN D-DIMER, HEMOSTATIC FACTORS, CARDIOVASCULAR-DISEASE, ENDOTHELIAL DYSFUNCTION, COAGULATION ACTIVATION, MYOCARDIAL-INFARCTION, SYSTEMIC MARKERS