Publication

Periodontitis is characterized by elevated PAI-1 activity

Bizzarro, S., van der Velden, U., ten Heggeler, J. M. A. G., Leivadaros, E., Hoek, F. J., Gerdes, V. E. A., Bakker, S. J. L., Gans, R. O. B., ten Cate, H. & Loos, B. G., Jul-2007, In : Journal of Clinical Periodontology. 34, 7, p. 574-580 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Objectives: Periodontitis is a chronic infectious disease and has been associated with cardiovascular diseases (CVD). We investigated whether plasma levels of markers of a prothrombotic state were elevated in patients with periodontitis in comparison with healthy controls.

Materials and methods: Untreated patients with moderate (n=53) and severe periodontitis (n=38) and healthy controls (n=39) were recruited. Levels of von Willebrand factor (vWF), prothrombin fragment 1+2 (F1+2), plasminogen activator inhibitor-1 (PAI-1) activity and D-dimer were measured as markers of a prothrombotic state.

Results: The erythrocyte sedimentation rate (ESR), plasma C-reactive protein (CRP) and leucocyte counts (WBC) were significantly higher in patients with periodontitis. No statistically significant difference was found among the three groups for vWF (p=0.264), F1+2 (p=0.295) and D-dimer (p=0.572). However, PAI-1 was clearly elevated in the severe periodontitis group (p=0.001), even after adjusting for potential confounding factors (p(adj)=0.004). Moreover, more patients than controls were having vWF and PAI-1 levels above the respective population medians.

Conclusions: In periodontitis, elevated levels of PAI-1 activity are observed compared with healthy controls. This may increase the potential for impaired fibrinolysis, a condition that results in a prothrombotic state. We suggest that this state, if left untreated, may contribute to an increased risk for CVD.

Original languageEnglish
Pages (from-to)574-580
Number of pages7
JournalJournal of Clinical Periodontology
Volume34
Issue number7
Publication statusPublished - Jul-2007

    Keywords

  • D-dimer, F1+2, PAI-1, periodontitis, vWF, CORONARY-HEART-DISEASE, C-REACTIVE PROTEIN, PLASMINOGEN-ACTIVATOR INHIBITOR-1, FIBRIN D-DIMER, HEMOSTATIC FACTORS, CARDIOVASCULAR-DISEASE, ENDOTHELIAL DYSFUNCTION, COAGULATION ACTIVATION, MYOCARDIAL-INFARCTION, SYSTEMIC MARKERS

ID: 4572456