Publication

Periodontal disease and pre-eclampsia: a systematic review

Kunnen, A., van Doormaal, J. J., Abbas, F., Aarnoudse, J. G., van Pampus, M. & Faas, M. M., Dec-2010, In : Journal of Clinical Periodontology. 37, 12, p. 1075-1087 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Kunnen, A., van Doormaal, J. J., Abbas, F., Aarnoudse, J. G., van Pampus, M., & Faas, M. M. (2010). Periodontal disease and pre-eclampsia: a systematic review. Journal of Clinical Periodontology, 37(12), 1075-1087. https://doi.org/10.1111/j.1600-051X.2010.01636.x

Author

Kunnen, Alina ; van Doormaal, Jasper J. ; Abbas, Frank ; Aarnoudse, Jan G. ; van Pampus, Maria ; Faas, Marijke M. / Periodontal disease and pre-eclampsia : a systematic review. In: Journal of Clinical Periodontology. 2010 ; Vol. 37, No. 12. pp. 1075-1087.

Harvard

Kunnen, A, van Doormaal, JJ, Abbas, F, Aarnoudse, JG, van Pampus, M & Faas, MM 2010, 'Periodontal disease and pre-eclampsia: a systematic review', Journal of Clinical Periodontology, vol. 37, no. 12, pp. 1075-1087. https://doi.org/10.1111/j.1600-051X.2010.01636.x

Standard

Periodontal disease and pre-eclampsia : a systematic review. / Kunnen, Alina; van Doormaal, Jasper J.; Abbas, Frank; Aarnoudse, Jan G.; van Pampus, Maria; Faas, Marijke M.

In: Journal of Clinical Periodontology, Vol. 37, No. 12, 12.2010, p. 1075-1087.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Kunnen A, van Doormaal JJ, Abbas F, Aarnoudse JG, van Pampus M, Faas MM. Periodontal disease and pre-eclampsia: a systematic review. Journal of Clinical Periodontology. 2010 Dec;37(12):1075-1087. https://doi.org/10.1111/j.1600-051X.2010.01636.x


BibTeX

@article{e3115e659d68455a8b3a40edfffa9735,
title = "Periodontal disease and pre-eclampsia: a systematic review",
abstract = "P>AimThis review evaluates the possible relationship between periodontal disease and pre-eclampsia, a major pregnancy complication. A generalized inflammatory response plays an important role in the pathogenesis of pre-eclampsia. Because periodontal disease is a low-grade inflammatory state, periodontal disease might contribute to the pathogenesis of pre-eclampsia.Main Findings and ConclusionA literature search of PubMed, EMBASE and CINAHL until August 2010 revealed 12 eligible observational studies and three randomized-controlled trials (RCTs). It appeared difficult to compare these studies, due to variations in definitions of periodontal disease and pre-eclampsia, timing of periodontal examination and inadequate control for confounding factors. Eight observational studies reported a positive association, while four studies found no association. None of the RTCs reported reductions in pre-eclamptic rate after periodontal therapy during pregnancy. Therefore, it is questionable whether periodontal disease plays a causal role in the pathogenesis of pre-eclampsia. The observed association in eight observational studies might be the result of induction of periodontal disease due to the pre-eclamptic state or it may be an epiphenomenon of an exaggerated inflammatory response to pregnancy. Larger RCTs with pre-eclampsia as the primary outcome and pathophysiological studies are required to explore causality and to dissect biological mechanisms involved.",
keywords = "immune response, inflammation, periodontal disease, pre-eclampsia, pregnancy, LOW-BIRTH-WEIGHT, BODY-MASS INDEX, RANDOMIZED-CONTROLLED-TRIAL, EARLY-ONSET PREECLAMPSIA, C-REACTIVE PROTEIN, PORPHYROMONAS-GINGIVALIS, INFLAMMATORY RESPONSE, PRETERM BIRTH, ENDOTHELIAL DYSFUNCTION, MATERNAL PERIODONTITIS",
author = "Alina Kunnen and {van Doormaal}, {Jasper J.} and Frank Abbas and Aarnoudse, {Jan G.} and {van Pampus}, Maria and Faas, {Marijke M.}",
year = "2010",
month = dec,
doi = "10.1111/j.1600-051X.2010.01636.x",
language = "English",
volume = "37",
pages = "1075--1087",
journal = "Journal of Clinical Periodontology",
issn = "0303-6979",
publisher = "Wiley",
number = "12",

}

RIS

TY - JOUR

T1 - Periodontal disease and pre-eclampsia

T2 - a systematic review

AU - Kunnen, Alina

AU - van Doormaal, Jasper J.

AU - Abbas, Frank

AU - Aarnoudse, Jan G.

AU - van Pampus, Maria

AU - Faas, Marijke M.

PY - 2010/12

Y1 - 2010/12

N2 - P>AimThis review evaluates the possible relationship between periodontal disease and pre-eclampsia, a major pregnancy complication. A generalized inflammatory response plays an important role in the pathogenesis of pre-eclampsia. Because periodontal disease is a low-grade inflammatory state, periodontal disease might contribute to the pathogenesis of pre-eclampsia.Main Findings and ConclusionA literature search of PubMed, EMBASE and CINAHL until August 2010 revealed 12 eligible observational studies and three randomized-controlled trials (RCTs). It appeared difficult to compare these studies, due to variations in definitions of periodontal disease and pre-eclampsia, timing of periodontal examination and inadequate control for confounding factors. Eight observational studies reported a positive association, while four studies found no association. None of the RTCs reported reductions in pre-eclamptic rate after periodontal therapy during pregnancy. Therefore, it is questionable whether periodontal disease plays a causal role in the pathogenesis of pre-eclampsia. The observed association in eight observational studies might be the result of induction of periodontal disease due to the pre-eclamptic state or it may be an epiphenomenon of an exaggerated inflammatory response to pregnancy. Larger RCTs with pre-eclampsia as the primary outcome and pathophysiological studies are required to explore causality and to dissect biological mechanisms involved.

AB - P>AimThis review evaluates the possible relationship between periodontal disease and pre-eclampsia, a major pregnancy complication. A generalized inflammatory response plays an important role in the pathogenesis of pre-eclampsia. Because periodontal disease is a low-grade inflammatory state, periodontal disease might contribute to the pathogenesis of pre-eclampsia.Main Findings and ConclusionA literature search of PubMed, EMBASE and CINAHL until August 2010 revealed 12 eligible observational studies and three randomized-controlled trials (RCTs). It appeared difficult to compare these studies, due to variations in definitions of periodontal disease and pre-eclampsia, timing of periodontal examination and inadequate control for confounding factors. Eight observational studies reported a positive association, while four studies found no association. None of the RTCs reported reductions in pre-eclamptic rate after periodontal therapy during pregnancy. Therefore, it is questionable whether periodontal disease plays a causal role in the pathogenesis of pre-eclampsia. The observed association in eight observational studies might be the result of induction of periodontal disease due to the pre-eclamptic state or it may be an epiphenomenon of an exaggerated inflammatory response to pregnancy. Larger RCTs with pre-eclampsia as the primary outcome and pathophysiological studies are required to explore causality and to dissect biological mechanisms involved.

KW - immune response

KW - inflammation

KW - periodontal disease

KW - pre-eclampsia

KW - pregnancy

KW - LOW-BIRTH-WEIGHT

KW - BODY-MASS INDEX

KW - RANDOMIZED-CONTROLLED-TRIAL

KW - EARLY-ONSET PREECLAMPSIA

KW - C-REACTIVE PROTEIN

KW - PORPHYROMONAS-GINGIVALIS

KW - INFLAMMATORY RESPONSE

KW - PRETERM BIRTH

KW - ENDOTHELIAL DYSFUNCTION

KW - MATERNAL PERIODONTITIS

U2 - 10.1111/j.1600-051X.2010.01636.x

DO - 10.1111/j.1600-051X.2010.01636.x

M3 - Review article

VL - 37

SP - 1075

EP - 1087

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

SN - 0303-6979

IS - 12

ER -

ID: 5208407