Periodontal disease and pre-eclampsia: a systematic reviewKunnen, A., van Doormaal, J. J., Abbas, F., Aarnoudse, J. G., van Pampus, M. & Faas, M. M., Dec-2010, In : Journal of Clinical Periodontology. 37, 12, p. 1075-1087 13 p.
Research output: Contribution to journal › Review article › Academic › peer-review
This review evaluates the possible relationship between periodontal disease and pre-eclampsia, a major pregnancy complication. A generalized inflammatory response plays an important role in the pathogenesis of pre-eclampsia. Because periodontal disease is a low-grade inflammatory state, periodontal disease might contribute to the pathogenesis of pre-eclampsia.
Main Findings and Conclusion
A literature search of PubMed, EMBASE and CINAHL until August 2010 revealed 12 eligible observational studies and three randomized-controlled trials (RCTs). It appeared difficult to compare these studies, due to variations in definitions of periodontal disease and pre-eclampsia, timing of periodontal examination and inadequate control for confounding factors. Eight observational studies reported a positive association, while four studies found no association. None of the RTCs reported reductions in pre-eclamptic rate after periodontal therapy during pregnancy. Therefore, it is questionable whether periodontal disease plays a causal role in the pathogenesis of pre-eclampsia. The observed association in eight observational studies might be the result of induction of periodontal disease due to the pre-eclamptic state or it may be an epiphenomenon of an exaggerated inflammatory response to pregnancy. Larger RCTs with pre-eclampsia as the primary outcome and pathophysiological studies are required to explore causality and to dissect biological mechanisms involved.
|Number of pages||13|
|Journal||Journal of Clinical Periodontology|
|Publication status||Published - Dec-2010|
- immune response, inflammation, periodontal disease, pre-eclampsia, pregnancy, LOW-BIRTH-WEIGHT, BODY-MASS INDEX, RANDOMIZED-CONTROLLED-TRIAL, EARLY-ONSET PREECLAMPSIA, C-REACTIVE PROTEIN, PORPHYROMONAS-GINGIVALIS, INFLAMMATORY RESPONSE, PRETERM BIRTH, ENDOTHELIAL DYSFUNCTION, MATERNAL PERIODONTITIS