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Perinatal fluoxetine exposure disrupts the circadian response to a phase-shifting challenge in female rats

Houwing, D. J., de Waard, J., Ramsteijn, A. S., Woelders, T., de Boer, S. F., Wams, E. J. & Olivier, J. D. A., 12-Jun-2020, In : Psychopharmacology. 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Rationale Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (SCN) is known to be modulated by serotonin and it is therefore assumed that SSRIs may affect circadian rhythms. However, effects of perinatal SSRI treatment on circadian system functioning in the offspring are largely unknown. Objective Our aim was to investigate the effects of perinatal exposure to the SSRI fluoxetine (FLX) on circadian behavior, affective behavior, and 5-HT(1A)receptor sensitivity in female rats. In addition, we studied the expression of clock genes and the 5-HT(1A)receptor in the SCN, as they are potentially involved in underlying mechanisms contributing to changes in circadian rhythms. Results Perinatal FLX exposure shortened the free-running tau in response to the 5-HT(1A/7)agonist 8-OH-DPAT. However, FLX exposure did not alter anxiety, stress coping, and 5-HT(1A)receptor sensitivity. No differences were found in 5-HT(1A)receptor and clock genes Per1, Per2, Cry1, and Cry2 SCN gene expression. Conclusions Perinatal FLX exposure altered the response to a phase-shifting challenge in female rats, whether this may pose health risks remains to be investigated.

Original languageEnglish
Number of pages14
JournalPsychopharmacology
Publication statusPublished - 12-Jun-2020

    Keywords

  • Fluoxetine, Pregnancy, Perinatal, Circadian behavior, Anxiety, Coping style, Clock genes, 5-HT1A receptor, Hypothermia, SEROTONIN REUPTAKE INHIBITORS, STRESS-INDUCED HYPERTHERMIA, HIPPOCAMPAL BDNF GENE, 5-HT1A RECEPTORS, SUPRACHIASMATIC NUCLEUS, PRENATAL EXPOSURE, IN-VITRO, PREGNANCY, CLOCK, MOUSE

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