Pd-Catalyzed de Novo Assembly of Diversely Substituted Indole-Fused Polyheterocycles

Wang, Q., Osipyan, A., Konstantinidou, M., Butera, R., Mgimpatsang, K. C., Shishkina, S. V. & Dömling, A., 20-Sep-2019, In : The Journal of Organic Chemistry. 84, 18, p. 12148-12156 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Here we describe a facile, tandem synthetic route for indolo[3,2-c]quinolinones, a class of natural alkaloid analogues of high biological significance. A Ugi four-component reaction with indole-2-carboxylic acid and an aniline followed by a Pd-catalyzed cyclization yields tetracyclic indoloquinolines in good to moderate yields. Commercially available building blocks yield highly diverse analogues in just two simple steps.
Original languageEnglish
Pages (from-to)12148-12156
Number of pages9
JournalThe Journal of Organic Chemistry
Issue number18
Publication statusPublished - 20-Sep-2019


  • article, catalysis, 2 indolecarboxylic acid, alkaloid, aniline, MULTICOMPONENT REACTIONS, INHIBITORS, DESIGN

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