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Patterns and mechanisms of evolutionary transitions between genetic sex-determining systems

van Doorn, G. S., Aug-2014, In : Cold Spring Harbor Perspectives in Biology. 6, 8, 17 p., 017681.

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  • Patterns and mechanisms of evolutionary transitions between genetic sex-determining

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DOI

The diversity and patchy phylogenetic distribution of genetic sex-determining mechanisms observed in some taxa is thought to have arisen by the addition, modification, or replacement of regulators at the upstream end of the sex-determining pathway. Here, I review the various evolutionary forces acting on upstream regulators of sexual development that can cause transitions between sex-determining systems. These include sex-ratio selection and pleiotropic benefits, as well as indirect selection mechanisms involving sex-linked sexually antagonistic loci or recessive deleterious mutations. Most of the current theory concentrates on the population-genetic aspects of sex-determination transitions, using models that do not reflect the developmental mechanisms involved in sex determination. However, the increasing availability of molecular data creates opportunities for the development of mechanistic models that can clarify how selection and developmental architecture interact to direct the evolution of sex-determination genes.

Original languageEnglish
Article number017681
Number of pages17
JournalCold Spring Harbor Perspectives in Biology
Volume6
Issue number8
Publication statusPublished - Aug-2014

    Keywords

  • DELETERIOUS MUTATION LOAD, DETERMINATION PATHWAY, ANTAGONISTIC SELECTION, XIPHOPHORUS-MACULATUS, CHROMOSOME TURNOVERS, HETEROGAMETIC SEX, TRANSFORMER GENE, Y-CHROMOSOME, CONFLICT, RATIO

ID: 15178984