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Patients with Diffuse Axonal Injury Can Recover to a Favorable Long-Term Functional and Quality of Life Outcome

van Eijck, M., van der Naalt, J., de Jongh, M., Schoonman, G., Oldenbeuving, A., Peluso, J., de Vries, J. & Roks, G., Oct-2018, In : Journal of Neurotrauma. 35, 20, p. 2357-2364 8 p.

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  • Patients with Diffuse Axonal Injury Can Recover to a Favorable Long-Term Functional and Quality of Life Outcome

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DOI

  • Marleen van Eijck
  • Joukje van der Naalt
  • Mariska de Jongh
  • Guus Schoonman
  • Annemarie Oldenbeuving
  • Jo Peluso
  • Jolanda de Vries
  • Gerwin Roks

Functional outcome and quality of life are difficult to predict in patients with diffuse axonal injury (DAI) after traumatic brain injury (TBI). The primary aim of this cross-sectional cohort study was to assess the long-term functional outcome in patients with DAI and to identify prognostic factors. Second, health-related quality of life (HRQL) at long-term follow-up was assessed. Patients >= 16 years of age with TBI and DAI (admitted 2008-2014) were included. Clinical and imaging data were collected. The primary outcome parameter was the Glasgow Outcome Scale Extended (GOSE) at long-term follow-up. Second, the HRQL was assessed with the Quality Of Life after Brain Injury (QOLIBRI) questionnaire. DAI was diagnosed in 185 patients. Long-term functional outcome was obtained in 134 patients (72%), median follow-up was 54 months (range 14-100); and 51% had a favorable outcome (GOSE 6-8). Independent prognostic factors were age, pupillary reaction, Hb, DAI grading, and return of consciousness

Original languageEnglish
Pages (from-to)2357-2364
Number of pages8
JournalJournal of Neurotrauma
Volume35
Issue number20
Publication statusPublished - Oct-2018

    Keywords

  • DAI, GOSE, HRQL, QOLIBRI, TBI, TRAUMATIC BRAIN-INJURY, CLOSED-HEAD INJURY, LONGITUDINAL MRI, CORPUS-CALLOSUM, LESIONS, PROGNOSIS, MODERATE, PREDICTION, IMPACT, SCALE

ID: 76183979