Patient-reported health outcomes in long-term lung transplantation survivors: A prospective cohort study

Parizi, A. S., Krabbe, P. F. M., Verschuuren, E. A. M., Hoek, R. A. S., Kwakkel-van Erp, J. M., Erasmus, M. E., van der Bij, W. & Vermeulen, K. M., Mar-2018, In : American Journal of Transplantation. 18, 3, p. 684-695 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

During the last three decades lung transplantation (LTx) has become a proven modality for increasing both survival and health-related quality of life (HRQoL) in patients with various end-stage lung diseases. Most previous studies have reported improved HRQoL shortly after LTx. With regard to long-term effects on HRQoL, however, the evidence is less solid. This prospective cohort study was started with 828 patients who were on the waiting list for LTx. Then, in a longitudinal follow-up, 370 post-LTx patients were evaluated annually for up to 15years. For all wait-listed and follow-up patients, the following four HRQoL instruments were administered: State-Trait Anxiety Inventory, Zung Self-rating Depression Scale, Nottingham Health Profile, and a visual analogue scale. Cross-sectional and generalized estimating equation (GEE) analysis for repeated measures were performed to assess changes in HRQoL during follow-up. After LTx, patients showed improvement in all HRQoL domains except pain, which remained steady throughout the long-term follow-up. The level of anxiety and depressive symptoms decreased significantly and remained constant. In conclusion, this study showed that HRQoL improves after LTx and tends to remain relatively constant for the entire life span.

This prospective cohort study follows lung transplant patients up to 15 years after transplantation and shows that health-related quality of life improves after transplantation and tends to remain relatively constant for the patient's entire life span.

Original languageEnglish
Pages (from-to)684-695
Number of pages12
JournalAmerican Journal of Transplantation
Issue number3
Early online date10-Sep-2017
Publication statusPublished - Mar-2018


  • clinical research, practice, epidemiology, health services and outcomes research, lung transplantation, pulmonology, qualitative research, quality of life (QOL), QUALITY-OF-LIFE, OBSTRUCTIVE PULMONARY-DISEASE, RATING DEPRESSION SCALE, INTERNATIONAL SOCIETY, SWEDISH-POPULATION, FUNCTIONAL STATUS, EMPLOYMENT STATUS, CYSTIC-FIBROSIS, SEX-DIFFERENCES, HEART
Related Prizes
  1. SHARE PhD Top Publication Award

    Ahmed Shahabeddin Parizi (Recipient), Paul Krabbe (Recipient) & Karin Vermeulen (Recipient), 10-Nov-2017


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