Publication

Patient Selection for Bronchoscopic Lung Volume Reduction

Welling, J. B. A., Hartman, J. E., Augustijn, S. W. S., Kerstjens, H. A. M., Vanfleteren, L. E. G. W., Klooster, K. & Slebos, D-J., 23-Apr-2020, In : International Journal of Chronic Obstructive Pulmonary Disease. 15, p. 871-881 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Purpose: Bronchoscopic lung volume reduction (BLVR) is a valuable treatment option for carefully selected patients with severe COPD. There is limited knowledge about the characteristics and outcomes of patients referred to a specialized center for BLVR. The study objectives were to investigate the selection rate for BLVR treatment in patients referred for this treatment and to investigate the differences between patients that were selected for BLVR and patients that were not. Patients and Methods: We performed a retrospective analysis of patients with severe COPD who were referred to our hospital to assess eligibility for BLVR treatment. Our parameters included demographics, comorbidity, chest computed tomography characteristics, reasons for rejection from BLVR treatment and patient survival. Results: In total, 1500 patients were included (mean age 62 years, 50% female and forced expiratory volume in 1 s 33% of predicted). Out of this group, 282 (19%) patients were selected for BLVR treatment. The absence of a suitable target lobe for treatment, an unsuitable disease phenotype and insufficient lung hyperinflation were the most important factors for not being selected. Patients that were selected for any BLVR option lived significantly longer than the group of patients that were not selected for BLVR (median 3060 versus 2079 days, P<0.001). Conclusion: We found that only a small proportion of patients that are referred for BLVR treatment is eligible for a BLVR treatment, indicating a need for both better referral tools and for the development of new therapies for this group of patients. Furthermore, our data suggest that selection for BLVR is associated with a significant survival benefit.

Original languageEnglish
Pages (from-to)871-881
Number of pages11
JournalInternational Journal of Chronic Obstructive Pulmonary Disease
Volume15
Publication statusPublished - 23-Apr-2020

    Keywords

  • bronchoscopic lung volume reduction, patient selection, endobronchial valves, lung volume reduction coils, ENDOBRONCHIAL VALVE THERAPY, COLLATERAL VENTILATION, HOMOGENEOUS EMPHYSEMA, CLINICAL-OUTCOMES, COIL TREATMENT, COMORBIDITIES, FEASIBILITY, SURVIVAL, SAFETY, TRIAL

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